Mar 3, 2014 · RA produced by ALDH1A1 can activate the RAR/RXR transcriptional complex, which in turn activates SREBP-1c. C/EBPβ and mucin1 can regulate Aldh1a1 in breast cancer cells. RA production can stimulate adipogenesis through ZFP423 and PPARγ.

SREBP-1c can up-regulate Aldh1a1 and Aldh1a2 in animals fed a high-fat diet. However, in females E2 can suppress Aldh1a2 . RA produced by ALDH1A1 can activate the RAR/RXR transcriptional...

Of three related ALDH1 genes, ALDH1A1 is most highly expressed in liver. ALDH1A1 is also rapidly gaining importance as a stem cell marker. We hypothesized that ALDH1A1 may have a broad cellular distribution in the liver, and that its expression may be regulated by RA and perturbed by inflammation.

May 3, 2012 · Retinoid metabolism is tightly controlled by an enzymatic network in which retinaldehyde dehydrogenases (Aldh1–3) are the rate-limiting enzymes that convert retinaldehyde to retinoic acid. Aldh1a1-deficient mice are protected from …

We employ a three-step developmental model to examine effects of Cyp1b1 and retinol on postnatal liver lipogenesis. Importantly, we show that Rdh11 and Aldh1a1, genes that appreciably determine liver retinaldehyde fate, fit within this network.

Mar 3, 2016 · In order to prove that SREBP-2 induces stemness through c-Myc regulation, loss- and gain-of-function experiments were conducted in SREBP-2-manipulated PCa cells, which showed that RNAi-mediated c-Myc knockdown reverted stem cell-like properties induced by SREBP-2 and decreased expression of ALDH1A1 and CD44 in …

Jan 1, 2018 · Because mice without ALDH1A1, a major RA synthesizing enzyme, are resistant to diet-induced obesity, we tested a hypothesis that pharmacological inhibition of RA synthesis can suppress weight gain in a murine model of diet-induced obesity.

Jul 21, 2023 · Insig1 deletion boosted SREBP1 nuclear localization, increasing Aldh1a1 transcriptional activity, causing excessive NAD + consumption and ER enlargement, and accelerating renal fibrosis. We identified nicardipine as a selective inhibitor of Aldh1a1-restored NAD + and ER homeostasis, which attenuated renal fibrosis.

Feb 6, 2020 · Use in situ hybridization to resolve effects on mRNA distributions of Aldh1a2 and Cyp26a1 (RA homeostasis); Hoxb1 and Pax6 (RA targets). Assess mice lacking Lrat and Rbp4 (DKO mice) that severely limits retinol supply to embryos.

Jan 1, 2021 · ALDH1A1, one important member of 19 ALDHs, can metabolize reactive aldehydes to their corresponding carboxylic acid derivatives and play important physiological and toxicological roles in many areas, including CNS, metabolic disorders, and cancers.