Chen et al. compiled five additional common ALDH2 missense variants with allele frequencies ranging from 0.6% to 2.5% in groups of African, Latino, South Asian and Finnish genetic ancestries (Chen et al., 2020).

In other words, the ALDH2 gene mutation is a protective factor in the alcohol-drinking population in East Asia, while it is weaker in European and African populations. 34 In fact, the Eastern culture encourages or challenges people to drink more alcohol in social activities, and sometimes people with flushing may not be able to escape or reject ...

Nov 7, 2019 · In a cohort of Hispanic donors, we identified 2 novel mutations in ALDH2. Using the ExAC genomic database, we found these identified variants and at least three other ALDH2 variants with a single point mutation among Latino, African, South Asian, and Finnish ethnic groups, at a frequency of >5/1000.

In addition to the well-characterized inhibitors of ALDH2, new research tools, including more selective inhibitors, transgenic mice with altered ALDH2 activity, and selective ALDH2 activators have shed new light on the role of ALDH2 in human diseases.

Background: Aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of aliphatic aldehydes, includ-ing acetaldehyde. About 45% of Han Chinese (East Asians), accounting for 8% of humans, carry a single point mutation in ALDH2*2 (E504K) that leads to accumulation of toxic reactive aldehydes.

Mar 16, 2022 · ALDH2 is a key enzyme in alcohol metabolism that protects cells from acetaldehyde toxicity. Using iHS, iSAFE and FST statistics, we identified regulatory acting variants affecting ALDH2 gene...

ALDH2 is a key enzyme in alcohol metabolism that protects cells from acetaldehyde toxicity. Using iHS, iSAFE and FST statistics, we identified regulatory acting variants afecting ALDH2 gene...

Using the ExAC genomic database, we found these identified variants and at least three other ALDH2 variants with a single point mutation among Latino, African, South Asian, and Finnish ethnic...

Using the ExAC genomic database, we found these identified variants and at least three other ALDH2 variants with a single point mutation among Latino, African, South Asian, and Finnish ethnic groups, at a frequency of >5/1000.

In one recent study (Spence et al. 2003) involving a variety of ethnic groups, including African Americans, the ALDH1A1*2 allele was found with a low frequency in several ethnic groups, whereas the ALDH1A1*3 allele was found only in African Americans.