We report that ACC1 Ser 79 /ACC2 Ser 212 phosphorylation is selectively important for promoting food intake and determining fuel utilization under cold stress, while AMPK-regulated energy …

Sep 13, 2018 · AMP-activated protein kinase (AMPK) α1 is activated in platelets on thrombin or collagen stimulation, and as a consequence, phosphorylates and inhibits acetyl-CoA …

Acetyl-CoA carboxylase (ACC), a target for the energy-sensing AMP-activating protein kinase (AMPK), is the major controller of the rate of FAO within cells. Metformin has a well described …

Nov 3, 2013 · Ampk phosphorylates mouse acetyl-CoA carboxylase 1 (Acc1; refs. 3,4) at Ser79 and Acc2 at Ser212, inhibiting the conversion of acetyl-CoA to malonyl-CoA.

AMPK acutely controls lipid metabolism via phosphorylation of ACC1 and ACC2, while mediating long-term adaptive effects via phosphorylation of Srebp1 and loss of expression of lipogenic …

Jul 7, 2014 · A double knock-in (DKI) mouse (ACC-DKI) model was generated in which the AMPK phosphorylation sites Ser79 on ACC1 and Ser221 (Ser212 mouse) on ACC2 were mutated to …

Sep 13, 2018 · AMPK-ACC signaling in platelets is a key mechanism regulating primary hemostasis and arterial thrombosis. AMPK-ACC signaling controls collagen-induced TXA 2 …

Apr 4, 2019 · Low glucose activates AMPK exclusively through the AMP-independent, AXIN-based pathway in lysosomes to phosphorylate targets such as ACC1 and SREBP1c, exerting …

Ampk phosphorylates mouse acetyl-CoA carboxylase 1 (Acc1; refs. 3,4) at Ser79 and Acc2 at Ser212, inhibiting the conversion of acetyl-CoA to malonyl-CoA. The latter metabolite is a …

Jul 2, 2019 · CircACC1 is preferentially produced over ACC1 in response to serum deprivation by the transcription factor c-Jun. It functions to stabilize and promote the enzymatic activity of the …