AMPK Plays a Dual Role in Regulation of CREB/BDNF Pathway …
Here, we found that AMP-activated protein kinase (AMPK) and CREB are oppositely regulated in mouse primary hippocampal neurons impaired by hypoxia-hypoglycemia. AMPK …
Regulation and function of AMPK in physiology and diseases
Jul 15, 2016 · In this review, we discuss the current understanding of the molecular and physiological regulation of AMPK and its metabolic and physiological functions. In addition, we …
AMP-activated protein kinase and its downstream transcriptional ...
AMPK anti-gluconeogenic effects are achieved through a combination of different transcriptional mechanisms. A constellation of transcriptional regulators modulates gluconeogenesis, such as …
AMP-activated protein kinase phosphorylates transcription factors …
Since previous reports show a cAMP response element in the promoter region of the hexokinase II gene, we hypothesized that the cAMP-response element (CRE) binding protein (CREB) …
Blockade of AMPK-Mediated cAMP-PKA-CREB/ATF1 Signaling
Apr 6, 2021 · Inhibition of AMP-activated protein kinase (AMPK) abrogates the induction of CREB/ATF1 phosphorylation by aspirin. Mechanistically, activation of AMPK by aspirin results …
Methotrexate-mediated activation of an AMPK-CREB-dependent …
We propose that low-dose MTX therapeutically conditions vascular endothelium via activation of AMPK-CREB signalling, so inducing cytoprotective genes which may contribute to the efficacy …
AMPK Plays a Dual Role in Regulation of CREB/BDNF Pathway in …
Feb 3, 2015 · AMPK overexpression reduced the CREB level via upregulating SIRT1 and negative posttranscriptional regulation by miR-134, suggesting a negative regulatory role of …
GLUT3 induced by AMPK/CREB1 axis is key for withstanding
Sep 2, 2020 · Mechanistically, low-glucose stress dramatically upregulated GLUT3 via the AMPK/CREB1 pathway. Furthermore, high GLUT3 expression remarkably increased the …
Blockade of AMPK-Mediated cAMP–PKA–CREB/ATF1 Signaling …
Apr 6, 2021 · Inhibition of AMP-activated protein kinase (AMPK) abrogates the induction of CREB/ATF1 phosphorylation by aspirin. Mechanistically, activation of AMPK by aspirin results …
Regulation and function of AMPK in physiology and diseases
AMPK inhibits gluconeogenesis by inhibiting several transcription factors, such as hepatocyte nuclear factor 4 (HNF4) and CREB regulated transcription coactivator 2 (CRTC2), that …
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