Our results reveal a novel FoxO1-dependent mechanism by which AMPK controls the expression of antioxidant enzymes and suggest that AMPK has an important role in maintaining redox homeostasis.

May 1, 2019 · The effect of AMPK activator AICAR on MHC and its isoforms expression was minimized by knockdown of FOXO1. Conclusions: The findings revealed that visfatin promoted expressions of MHC and its isoforms in C2C12 myotubes via suppressing AMPK/FOXO1 signaling pathway.

Aug 30, 2019 · AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, partly mediates this effect through phosphorylation of Ser 383 and Thr 649 in FOXO1. In this study, we identified Ser 22 as an additional AMPK phosphorylation site in FOXO1's N terminus, with Ser 22 phosphorylation preventing binding of 14-3-3 proteins.

May 20, 2024 · Hyperactivation of AMPK in TAZ-KO C2C12 cells represents a key finding in the current study; inhibition of AMPK led to reduced levels of PDK4, PDH phosphorylation, and FOXO1 nuclear localization.

Jul 26, 2014 · Our results reveal a novel FoxO1-dependent mechanism by which AMPK controls the expression of antioxidant enzymes and suggest that AMPK has an important role in maintaining redox homeostasis.

Jan 9, 2025 · In oxidative stress conditions, AMPK, an energy sensor, activates SIRT1, which in turn stimulates the FOXO transcription factor. This cascade enhances mitochondrial function, reduces mitochondrial damage, and mitigates OS-induced cellular injury.

Aug 8, 2019 · AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, partly mediates this effect through phosphorylation of Ser 383 and Thr 649 in FOXO1. In this study, we identified Ser 22 as an additional AMPK phosphorylation site in FOXO1's N terminus, with Ser 22 phosphorylation preventing binding of 14-3-3 proteins.

May 1, 2019 · Given that AMPK and FOXO1 were both involved in visfatin-induced expressions of MHC and its isoforms, and FOXO1 could be a downstream target of AMPK, we then investigated whether AMPK works together with FOXO1 in regulation of MHC expression.

Our recent results indicate that FoxO transcription factors are also regulated in response to nutrient deprivation by the AMP-activated protein kinase (AMPK) pathway. The energy-sensing AMPK directly phosphorylates FoxO transcription factors at six regulatory sites.

1 day ago · In cancer cells, IDH2 levels increased adaptively upon metabolic stress via the AMPK-FOXO1 pathway . Rd led to drastic AMPK activation, which in turn triggered the nuclear translocation of FOXO1 (Fig. 8e and Fig. S7c). ChIP assay suggested that FOXO1 antibody could expectedly enrich the DNA of IDH2 promoter region, and Rd strengthened the ...