The introduction of alkylamino or dialkylamino groups possessing strong donor properties has the most pronounced effect on the mobility of the chlorine atom and, what is very important, this effect is different in different cases <2002RCB105>.

alkylamino group: ChEBI ID CHEBI:22332: Definition Alkyl substituents attached to the remainder of a molecule via nitrogen. Stars This entity has been manually annotated by the ChEBI Team.

Alkylamino moieties in drug molecules undergo two types of metabolic reactions: N-dealkylation and N-oxidation. The former metabolic change has resulted in clinically used drugs, potential drugs, activation of prodrugs as well as attenuation and loss of activity of drugs.

Ethylethanolamine (EEOA) is used mainly as a building block in the pharmaceutical industry. N,N-Dimethylethanolamine S (DMEOA, DMAE) belongs to the class of N-alkylated aminoalcohols. DMEOA is a colorless to slightly yellow liquid with a amine-like odor.

Apr 13, 2021 · Alkylamino moieties, either open chain aliphatic (secondary or tertiary), or heterocyclic tertiary ones, are common in drug molecules of various pharmacological classes. Their basicity and polarity are essential for drug action.

Apr 20, 2024 · alkylamino (plural alkylaminos) (organic chemistry) A group or radical containing both an alkyl and an amino group

The meaning of ALKYLAMINO is of, relating to, or containing an alkylamine.

Iodine‐Mediated Sulfonylation of Quinoline N ‐Oxides: a Mild and Metal‐Free One‐Pot Synthesis of 2‐Sulfonyl Quinolines.

Mar 29, 2021 · While both secondary and tertiary alkylamino moieties (open chain aliphatic or heterocyclic) are metabolized by CYP450 isozymes oxidative N -dealkylation, only tertiary alkylamino moieties are subject to metabolic N -oxidation by Flavin-containing monooxygenase (FMO) to give N -oxide products.

May 19, 2024 · Stiffening the alkylamino group with an aliphatic bridge and an aromatic ring promotes charge transfer in the ground state. The linear solvation energy (LSE) analysis shows that dipolarity/polarizability interactions mainly contribute to solvent-induced spectral shifts.