Alpha-actinin-3, also known as alpha-actinin skeletal muscle isoform 3 or F-actin cross-linking protein, is a protein that in humans is encoded by the ACTN3 gene (named sprinter gene, …

ACTN3 is a gene that encodes for alpha-actinin-3, a protein expressed only in type-II muscle fibers (North et al., 1999). A common polymorphism in this gene is R577X (rs1815739), where …

Jun 20, 2022 · The ACTN3 gene encodes the alpha actinin 3 protein found in fast-twitch muscles. Fast-twitch muscles are responsible for explosive bursts of power or speed. A common …

Apr 1, 2016 · α-Actinin-3 deficiency influences human muscle performance. Structural, metabolic, signalling and calcium handling pathways are altered. Molecular mechanisms underlying the …

The human sarcomeric alpha-actinins (ACTN2 and ACTN3) are major structural components of the Z line in skeletal muscle; they play a role in the maintenance of sarcomeric integrity and …

Alpha-actinin 3 (ACTN3) is a constituent of the Z-line in skeletal muscle fibers and is crucial for binding actin fibrils during muscle contraction. Three genotypes of ACTN3 exist: RR, RX, and …

Dec 24, 2024 · This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural …

The human ACTN3 gene encodes the protein alpha-actinin-3, a component of the contractile apparatus in fast skeletal muscle fibers. In 1999, we identified a common polymorphism in …

The alpha-actinins are an ancient family of actin-binding proteins that play structural and regulatory roles in cytoskeletal organisation and muscle contraction. alpha-actinin-3 is the …

May 14, 2021 · ACTN3 is an actin-binding protein specifically expressed in fast skeletal muscle fibers (Garton et al., 2018). Alpha-actinin is an actin-binding protein with multiple roles in …