The pK a values and the isoelectronic point, pI, are given below for the 20 α-amino acids. pKa 1 = α-carboxyl group, pK a2 = α-ammonium ion, and pK a3 = side chain group.

Understanding pKa, zwitterions, and isoelectric points in amino acids is critical in comprehending the behavior and properties of proteins and their functional groups.

pKa and pI values of amino acids ... www.peptideweb.com Custom peptide synthesis | Equipment, glassware and reagents for peptide synthesis

1 pKa is the negative of the logarithm of the dissociation constant for the -COOH group. 2 pKb is the negative of the logarithm of the dissociation constant for the -NH3 group.

Understand the classification of proteinogenic amino acids based on the characteristics of the side chain. Define isoelectric point and understand the ionization states of amino acids under …

This page provides detailed information about amino acids, their structure, properties, and functions.

Amino acids by themselves have amino (pKa ~9.0-10.5) and carboxyl groups (pKa ~2.0-2.4) that can be titrated. At neutral pH the amino group is protonated, and the carboxyl group is deprotonated.

The proteinogenic amino acids are amphoteric and have two or three pK values, depending on their side chains. pKa1 is the α-carboxyl group, pKa2 is the α-ammonium ion, pKa3 is the side chain group if applicable and pI is the isoelectric point at which the amino acid has no net charge.

In computational biology, protein pKa calculations are used to estimate the p Ka values of amino acids as they exist within proteins. These calculations complement the p Ka values reported for amino acids in their free state, and are used frequently within the fields of molecular modeling, structural bioinformatics, and computational biology.

Jan 15, 2025 · The pKa amino acid table is a valuable resource for studying these properties, providing the pKa values of all 20 standard amino acids at physiological pH (7.4). It is essential for determining the ionization state of amino acids in proteins, which influences their solubility, activity, and interactions with other molecules.