Axonal Transport Not Bothered by Tau Elevation In Vivo
Feb 27, 2008 · Indeed, there is growing evidence that failed axonal transport might be the underlying basis for several neurodegenerative diseases in addition to tauopathies (8). It is …
Axonal transport rates in vivo are unaffected by tau deletion or ...
Feb 27, 2008 · Indeed, there is growing evidence that failed axonal transport might be the underlying basis for several neurodegenerative diseases in addition to tauopathies (8). It is …
Presenilin Mutations Stall Endosomal Transport, Swell Axons
May 5, 2022 · LE acidification and axonal transport appeared normal in cortical slices from 6-month-old mice, but as they got older, axonal transport declined. In cortical slices from 13 …
PLD3 affects axonal spheroids and network defects in Alzheimer's ...
Jan 3, 2023 · Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci. 2011 May …
Huntington’s Protein Snarls Axonal Traffic - ALZFORUM
Oct 2, 2003 · Two papers in the 25 September Neuron move axonal transport squarely into the limelight of research on triplet-repeat (or polyQ) diseases, including Huntington’s. One team of …
The Skinny on FAT: APP’s Role in Fast Axonal Transport
Nov 3, 2006 · APP C-terminal Drives Fast Axonal Transport Fluorescent virus-sized particles coupled to the C-terminal (red) of APP drive fast anterograde transport when injected into the …
Axonal transport of late endosomes and amphisomes is selectively ...
May 5, 2022 · Apparently, reduced acidification of late endosomes/amphisomes disturbs their retrograde cellular transport mediated by the motor protein dynein. In this signaling cascade …
Axonal transport of TDP-43 mRNA granules is impaired by ALS …
The authors were able to demonstrate that TDP-43 is implicated in the anterograde axonal transport of specific mRNAs from the soma to distal axonal compartments, including the …
Defective Axonal Transport Puts Tau in a Tizzy - ALZFORUM
May 11, 2009 · Scientists know that mutant tau interferes with axonal transport. The explanation for wild-type tau tangles may be that transport deficiencies, in turn, cause tauopathy. In the …
Mitochondrial Gridlock—Syntaphilin Puts Brakes on Axonal …
Jan 23, 2008 · Increasing axonal transport of mitochondria could be beneficial, since it may allow damaged mitochondria to return to the nucleus where they may be repaired or …