C57BL/6, often referred to as "C57 black 6", "B6", "C57" or "black 6", is a common inbred strain of laboratory mouse. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease.

C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis.

C57BL/6 mice from Charles River provide an ideal invivo platform for various research applications including immunology, metabolic diseases, genetics and model creation. The Charles River B6 mouse is available globally.

Aged C57BL/6J mice have research applications that include immunology, cancer, longevity interventions, and biomarker studies. C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced.

Sep 28, 2023 · Learn about finding and selecting mouse models, the basics of mouse nomenclature, the importance of choosing the appropriate controls for your experiment, and …

The C57BL/6 mouse – sometimes called the B6 or Black 6 mouse – is among the most useful mouse models in preclinical research, owing to its utility in metabolic studies and popularity as a genetic engineering platform.

The advantage of choosing among B6 substrains as opposed to other inbred strains is that the results might be more applicable for reverse genetic studies (e.g., knockouts and transgenics), which overwhelmingly use B6 mice.

The Black 6 (B6) mouse model is one of the most reliable and consistent inbred strains used in biomedical research. Known for its uniform genetic makeup, the C57BL/6 strain is ideal for researchers who require highly reproducible results across experiments.

Here are three ways in which B6J mice differ from B6N mice: 1. Mice on the C57BL/6N genetic background carry the Crb1 mutation. Photoreceptor degeneration is observed in spots, caused by retinal folds and pseudorosettes, found in the fundus of the eye of all vendor lines of the C57BL/6N line (Mattapallil et al. 2012).

Oct 2, 2017 · Inbred mice are critical tools in biomedical research and one particular strain, known as C57BL/6 (Black 6 or B6, for short), is rapidly becoming the standard model for many applications and revolutionising modern research.