Comparative Analysis of Evolutionary Mechanisms of the …
In contrast, the BM2 protein of lineages II and III was observed to be evolving at rates of 3.80 × 10 −3 and 3.46 × 10 −3 aas/st/yr, respectively, which were unexpectedly higher than those of the …
Influenza B Virus BM2 Protein Is a Crucial Component for …
Influenza B virus contains four integral membrane proteins in its envelope. Of these, BM2 has recently been found to have ion channel activity and is considered to be a functional …
The Transmembrane Conformation of the Influenza B Virus M2 …
Mar 6, 2019 · Influenza A and B viruses cause seasonal flu epidemics. The M2 protein of influenza B (BM2) is a membrane-embedded tetrameric proton channel that is essential for the …
Atomic structures of closed and open influenza B M2 proton …
Feb 3, 2020 · Here we report 1.4- and 1.5-Å solid-state NMR structures of the transmembrane domain of the closed and open BM2 channels in a phospholipid environment. Upon activation, …
Solution structure and functional analysis of the influenza B proton ...
Nov 8, 2009 · Influenza B virus contains an integral membrane protein, BM2, that oligomerizes in the viral membrane to form a pH-activated proton channel. Here we report the solution …
Influenza B virus M2 protein can functionally replace its influenza …
Nov 1, 2016 · Flu A M2 protein (AM2) can be functionally replaced by that of Flu B (BM2). Both AM2 and BM2 with extended cytoplasmic tail are functional. Compatibility between the ion …
Chemical synthesis of membrane proteins: a model study on the …
In the present study we have developed and optimized a robust strategy for the synthesis of highly hydrophobic peptides, especially membrane proteins, exemplarily using the influenza B …
The Transmembrane Conformation of the Influenza B Virus M2
Mar 6, 2019 · Influenza A and B viruses cause seasonal flu epidemics. The M2 protein of influenza B (BM2) is a membrane-embedded tetrameric proton channel that is essential for the …
The Potential of Cyclodextrins as Inhibitors for the BM2 Protein
Jan 28, 2024 · The influenza BM2 transmembrane domain (BM2 TM), an acid-activated proton channel, is an attractive antiviral target due to its essential roles during influenza virus …
Influenza B virus BM2 protein is an oligomeric integral membrane ...
Feb 1, 2003 · The findings that BM2 and A/M2 anism, BM2 contains 109 residues and is oligomeric, have distinct TM domains that leads to largely protonmost likely a tetramer …