P. acnes is a gram-positive commensal bacterium that causes acne on the skin. P. acnes releases lipase that produces fatty acids by digesting sebum, creating inflammation of the skin. Several Kampo medicines and their ingredients have been described for their inhibitory effect on the growth of bacteria.

Propionibacterium acnes is known primarily as a skin commensal. However, it can present as an opportunistic pathogen via bacterial seeding to cause invasive infections such as implant-associated infections.

P. acnes was identified using the MicroScan rapid anaerobe identification method (Siemens Healthcare, W. Sacramento, CA). We tested this strain collection against a panel of 10 antibiotics, with an emphasis on antibiotics that might actually be …

Jan 16, 2025 · Propionibacterium acnes, commonly associated with acne development, plays a role in the skin’s microbial community. Understanding its dual nature as both a commensal organism and a potential pathogen is essential for comprehending its impact on human health.

This review provides results of the most recent biochemical and genomic investigations that led to the new taxonomic classification of P. acnes renamed Cutibacterium acnes (C. acnes), and to the better characterisation of its phylogenetic cluster groups.

P. acnes isolated as an uncertain significant pathogen in 47 patients, predominantly from routine preoperative conjunctival swabs (n=22) in the absence of suspension of infection and inflammation in the eye followed by decryocystitis (n=9) and keratitis (n=1).

May 13, 2019 · We conclude with a discussion of new therapeutic strategies that are currently under investigation for acne vulgaris, including vaccination, and consider the potential of these treatments to also perturb beneficial lineages of P. acnes on the skin.

Jun 27, 2016 · Among different types of microbial populations, Propionibacterium acnes is the predominant member in the skin areas of back, face and chest. Although this bacterium is part of the normal...

Although the relative abundances of P. acnes may be similar among patients with acne and individuals without acne, P. acnes populations and the presence of P. acnes biofilms differ, with different potential virulence properties and antimicrobial resistance patterns.

The capability of four different strains of P acnes to activate the innate immune response and the growth of keratinocytes has been found. Distinct strains of P acnes significantly induced human β-defensin-2 messenger RNA (mRNA) expression, and all four strains significantly induced IL-8 expression. All of these effects could be inhibited by ...