Blimp-1 controls plasma cell function through regulation of ...
Here we have used a genetic approach to investigate the functional consequences of the loss of either IRF4, Blimp-1 or XBP-1 in mature post-mitotic BM PCs. To assess the importance of …
BLIMP1 guides the fate of effector B and T cells - Nature
Recombination-activating gene 1 (Rag1) −/− mice reconstituted with fetal liver cells homozygous for Blimp1GFP recapitulate the phenotype of mice with the B-cell-specific deletion of BLIMP1 in...
Blimp1 regulates development of the posterior forelimb, caudal ...
Blimp1 plays essential roles in multipotent progenitor cell populations in the posterior forelimb, caudal pharyngeal arches, secondary heart field and sensory vibrissae and maintains key …
The Blimp-1 gene regulatory region directs EGFP expression in …
The B lymphocyte-induced maturation protein-1 (Blimp-1) is a transcriptional repressor involved in B cell terminal differentiation. Recent studies suggest that it also plays roles in the …
Transcriptional repressor Blimp-1 is essential for T cell ... - Nature
Mar 26, 2006 · Mice reconstituted with fetal liver stem cells expressing a mutant Blimp-1 lacking the DNA-binding domain developed a lethal multiorgan inflammatory disease caused by an …
The transcription factors Blimp-1 and IRF4 jointly control the ...
Mar 6, 2011 · Here we demonstrate that expression of the transcription factor Blimp-1 defined a population of T reg cells that localized mainly to mucosal sites and produced IL-10. Blimp-1 …
A role for Blimp1 in the transcriptional network controlling natural ...
Feb 10, 2011 · Blimp1gfp/gfp: Ly5.1 mixed bone-marrow chimeras were generated by reconstituting lethally irradiated Ly5.1 recipients with a mixture of bone-marrow cells isolated …
| A Blimp-1-GFP dim population is found in the germinal center …
GC localized Blimp-1-GFP + cells were detected in 11 separate mice from 2 experiments (I) or 7 mice from 3 experiments (J). Data in H is from two independent experiments but population V...
The Blimp-1 gene regulatory region directs EGFP expression in …
Sep 19, 2007 · We present here our experimental evidence that the 4.4 kb Blimp-1 promoter sequence is sufficient to direct EGFP (enhanced green fluorescent protein) reporter gene …
Expression of the Plasma Cell Transcriptional Regulator Blimp-1 …
GFP detection thresholds were set using GC B cells from GFP negative (neg) wild type (WT) mice. As expected (14, 16, 23, 28), small but distinct GC B cell subsets were Blimp-1-GFP + in …
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