Jun 12, 2023 · Brexanolone is a medication used in the treatment of postpartum depression in adult women. It is in the GABA-A modulator class of medications. This activity describes the indications, contraindications, pharmacodynamics, pharmacokinetics, and monitoring for brexanolone as a valuable agent in treating postpartum depression.

Sep 14, 2021 · Brexanolone enhances the inhibitory effects of GABA A, restores dysfunctional GABA A transmembrane channels, and mimics a naturally produced progesterone metabolite that fluctuates during pregnancy and postpartum.

Sep 13, 2021 · Brexanolone enhances the inhibitory effects of GABA A, restores dysfunctional GABA A transmembrane channels, and mimics a naturally produced progesterone metabolite that fluctuates during pregnancy and postpartum.

May 29, 2019 · Brexanolone, an intravenous formulation of the endogenous neurosteroid allopregnanolone, showed clinically significant antidepressant activity in postpartum depression. By allosterically enhancing GABA A receptor function, the antidepressant activity of allopregnanolone is attributed to an increase in GABAergic inhibition.

Brexanolone targets GABAergic synapses and extrasynaptic GABA A Rs nonspecifically throughout the brain, leading to concerns about adverse sedation-related events.

The neurosteroid, brexanolone (BX), is a progesterone-derived allopregnanolone that rapidly relieves anxiety and mood deficits by activating GABA-A receptors, making it a transformational treatment for PPD.

Oct 20, 2016 · Brexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA (a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women Label 1, 2, 7, 8, 9.

Aug 11, 2023 · The neurosteroid, brexanolone (BX), is a progesterone-derived allopregnanolone that rapidly relieves anxiety and mood deficits by activating GABA-A receptors, making it a transformational treatment for PPD.

Oct 10, 2024 · Antidepressant, a γ-aminobutyric acid type A (GABA A) receptor positive modulator. Treatment of postpartum depression in patients ≥15 year of age. American College of Obstetricians and Gynecologists (ACOG) recommends psychotherapy as first-line treatment for mild-to-moderate perinatal depression.

Sep 28, 2017 · Brexanolone (SAGE 547) is a neuroactive steroid and positive allosteric modulator of both synaptic and extra-synaptic GABA-A receptors. Brexanolone showed promising results in a small, but diverse sample of women with severe PPD, in a recently published double-blind, randomized, and placebo-controlled study [15].