Memory B cells (MBCs), which provide protection against antigen re-exposure 1–3, can differentiate into antibody-forming cells (AFCs) and make new antibodies, or enter germinal centers (GCs) and provide a renewed source of lasting B cell immunity.

Further, expression of CD73, CD80 and CD273 has allowed the categorization of B-cell memory into multiple subsets, with combinatorial expression of the markers increasing with GC progression, isotype-switching and acquisition of somatic mutations.

Further, expression of CD73, CD80 and CD273 has allowed the categorization of B‐cell memory into multiple subsets, with combinatorial expression of the markers increasing with GC progression, isotype‐switching and acquisition of somatic mutations.

In mice, CD19, CD80, CD73, and PD-L2/CD273 are commonly used to identify memory B cells. Differential expression of these markers suggests that there are at least five distinct mouse memory B cell subsets.

IgM + and IgM − MBCs that co-express CD73 and CD80 can differentiate into plasmablasts and germinal center B cells after re-challenge with P. yoelii. Memory B cells (MBCs) represent a population of B cells that protect the host upon antigen (Ag) re-encounter.

Dec 15, 2010 · In this article, we show that, together, PD-L2 (CD273), CD80, and CD73 define at least five phenotypic subsets of murine memory B cells. These subsets are generated from naive cells bearing a single BCR in response to a single T-dependent Ag.

Infection of mice with P. yoelii 17X resulted in 2 predominant MBC populations: somatically hypermutated isotype-switched (IgM - ) and IgM + MBCs that coexpressed CD73 and CD80 that produced antigen-specific antibodies in response to secondary infection.

1 day ago · IgE-expressing B cells fail to form memory B cells (MBCs). Nelson et al. show that inhaled allergen induces the formation of lung-resident MBCs with IgG1+ MBCs class switching to IgE driven by interleukin-4 from lung Th2 cells. ... MBC subsets with different functions can be identified based on expression of CD80, CD73, and PD-L2. 47, 48 ...

Mar 1, 2023 · Not until relatively recently have a set of markers - CD73, CD80, PD-L2 - been identified that can distinguish MBCs from naïve B cells in mice . These markers have been used to examine typical T-cell dependent immune responses, e.g., against the hapten NP or sheep red blood cells (SRBC) ( 10 , 11 ).

Mar 24, 2014 · Here, we demonstrate that CD73 is progressively upregulated on germinal center (GC) B cells following immunization, is expressed at even higher levels among T follicular helper cells, but is absent among plasma cells (PC) and plasmablasts (PB).