Arabidopsis COP1 SUPPRESSOR 2 Represses COP1 E3 Ubiquitin …
CSU2 directly interacts with COP1 via their coiled-coil domains and is recruited by COP1 into nuclear speckles in living plant cells. Furthermore, CSU2 inhibits COP1 E3 ubiquitin ligase …
Cryptochrome 2 competes with COP1 substrates to repress COP1 ... - PNAS
Dec 10, 2019 · Here we show that CRY2 inhibits COP1 by displacing degradation substrates from COP1. This mechanism requires a valine-proline (VP) motif present in the C-terminal domain …
Functional dissection of Arabidopsis COP1 reveals specific roles of …
Oct 1, 1998 · Arabidopsis COP1 acts as a repressor of photomorphogenesis in darkness, and light stimuli abrogate the repressive ability and nuclear abundance of COP1. COP1 has three …
DET1 dynamics underlie cooperative ubiquitination by CRL4DET1-COP1 …
Feb 26, 2025 · Biochemical assays suggest that the E2 acts as a recruitment factor to bring COP1 to DET1 for more effective substrate ubiquitination, which parallels a catalytically inactive E2 …
COP1 - from plant photomorphogenesis to mammalian tumorigenesis
The COP1 (constitutive photomorphogenic 1) protein, comprising RING finger, coiled-coil and WD40 domains, is conserved in both higher plants and vertebrates. In plants, COP1 acts as …
Functional dissection of Arabidopsis COP1 reveals specific roles of …
Oct 1, 1998 · Arabidopsis COP1 acts as a repressor of photomorphogenesis in darkness, and light stimuli abrogate the repressive ability and nuclear abundance of COP1. COP1 has three …
Arabidopsis COP1 SUPPRESSOR 2 Represses COP1 E3 Ubiquitin …
Dec 29, 2015 · CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) functions as an E3 ubiquitin ligase and mediates a variety of developmental processes in Arabidopsis by targeting a …
The Photomorphogenic Central Repressor COP1: Conservation …
May 11, 2020 · COP1 protein contains three functional domains required for its activity: an N-terminal RING-finger domain, a middle coiled-coil domain, and a C-terminal WD40 domain …
The activities of the E3 ubiquitin ligase COP1/SPA, a
Jun 1, 2017 · COP1 SUPPRESSOR2 (CSU2) is a coiled-coil protein that interacts with the coiled-coil domain of COP1 and thereby represses the in vitro E3 ubiquitin ligase activity of …
Functional dissection of Arabidopsis COP1 reveals specific roles of …
COP1 has three known structural modules: an N-terminal RING-finger, followed by a predicted coiled-coil and C-terminal WD-40 repeats. A systematic study was undertaken to dissect the …