The coatomer is a protein complex [1] that coats membrane-bound transport vesicles. Two types of coatomers are known: COPI (retrograde transport from trans-Golgi network to cis-Golgi network and endoplasmic reticulum) COPII (anterograde transport from ER to the cis-Golgi)

Coatomer is a soluble macromolecular complex involved in membrane traffic through the Golgi complex and contains seven nonidentical protein subunits (α, β, β′, γ, δ, ε, and ζ) termed coat proteins (COPs).

Apr 28, 2022 · Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the endoplasmic reticulum (ER) and within Golgi compartments. Deficiency in subunit alpha causes COPA syndrome...

We discuss the structural motifs defining these three membrane-coating complexes and suggest that compared with BAR and ESCRT, the coatomer architecture had a unique ability to be readily and considerably modified, unlocking functional diversity and enabling the development of …

Coatomer is a cytosolic protein complex that forms the coat of COP I- coated transport vesicles. In our attempt to analyze the physical and functional interactions between its seven subunits (coat proteins, [COPs] alpha-zeta), we engaged in a ...

In this study, we describe the characterization and crystal structures of αβ′-COP and αε-COP subcomplexes of the coatomer cage. Based on this analysis we propose a model for the COPI cage based on a triskelion vertex with striking similarities to both COPII and clathrin.

Jan 1, 2001 · We have now identified and purified a cytosolic complex containing the same four coat proteins as those of Golgi transport vesicles. We term this complex the Golgi coat promoter or 'coatomer'. The coatomer also contains polypeptides of Mr 36K, 35K and 20K.

Jan 1, 2020 · In 1994, a convergence of ideas and collaborative research orchestrated by Randy Schekman led to the discovery of the coat protein complex II (COPII). In this Perspective, the chain of events enabling discovery of a new vesicle coat and progress on understanding COPII budding mechanisms are considered.

Jul 29, 2016 · The core component of the COPI complex is coatomer, which is a multimeric complex that needs to be recruited from the cytosol to membrane in order to function in membrane bending and cargo sorting.

Jul 9, 2010 · Coatomer complexes, attached to the membrane surface through ARF-GTP, can bind cargo molecules and then self-assemble to form spherical cages that yield COPI-coated vesicles (Bremser et al., 1999, Nickel et al., 1998, Orcl et al., 1993, Spang et al., 1998).