Cyclins are generally very different from each other in primary structure, or amino acid sequence. However, all members of the cyclin family are similar in 100 amino acids that make up the cyclin box. Cyclins contain two domains of a similar all-α fold, the first located at the N-terminus and the second at the C-terminus. All cyclins are ...

Jul 19, 2023 · The cell cycle is regulated by cyclins, a type of protein that binds and activates cyclin dependent kinases (CDKs).

Cyclin F plays a role in cell cycle regulation through selective ubiquitination or binding of cell cycle proteins. • Cyclin F is involved in DNA synthesis and repair mechanisms, important in the context of genotoxic stress. • Cyclin F dysfunction has been linked to cancer, amyotrophic lateral sclerosis and frontotemporal dementia.

Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle and transcription, as well as communication, metabolism, and apoptosis. The kinases are organized in a pathway to ensure that, during cell division, each cell ...

Jan 13, 2025 · Cyclin Dependent Kinases (CDKs) are closely connected to the regulation of cell cycle progression, having been first identified as the kinases able to drive cell division.

Jan 13, 2025 · Cyclin Dependent Kinases (CDKs) are closely connected to the regulation of cell cycle progression, having been first identified as the kinases able to drive cell division. In reality, the human genome contains 20 different CDKs, which can be divided in at least three different sub-family with differ …

Feb 26, 2025 · Cyclin B-CDK1 is a really important kinase because in the beginning of the prophase, it phosphorylates the lamina. Lamina is an intermediate filament that supports the nuclear envelope. So, it leads to breakdown of the nuclear envelope, the nuclear gets separated and chromosomes get condensed. So, lamina dissociation is a n important event ...

Cyclin D1 overexpression is found in more than 50% of human breast cancers and causes mammary cancer in transgenic mice. Dysregulation of cyclin D1 gene expression or function contributes to the loss of normal cell cycle control during tumorigenesis.

Key components of the cell cycle machinery are the regulatory sub-units, the cyclins, and their catalytic partners, the cyclin-dependent kinases. Some of the cyclins exhibit unique patterns of expression in germ cells that suggest possible concomitant distinct functions, predictions that are being explored by targeted mutagenesis in mouse models.

Coordinated protein phosphorylation reactions control progression through the cell cycle. Learn how specific complexes of cyclins and cyclin-dependent kinases (CDKs) catalyze these reactions.