Sep 11, 2024 · Partial D is a “D variant” like “Weak D.” Current recommendations suggest testing D variant blood recipients and pregnant females with molecular testing to further evaluate the risk of receiving D-positive blood in recipients or developing anti-D in D variant pregnant females.

Sep 11, 2024 · Weak D occurs when a D-positive person has a form of the antigen that reacts less strongly than normal (or not at all) in routine testing.

Mar 22, 2024 · Among the over 50 Rh blood group system antigens, the D antigen is one of the most clinically significant, dictating RhD-positive or RhD-negative blood types. However, within RhD positivity lies a subtle yet crucial variation known as the weak D antigen, or Du phenotype.

Approximately 0.2% to 1% of routine RhD blood typings result in a “serological weak D phenotype.” For more than 50 years, serological weak D phenotypes have been managed by policies to protect RhD-negative women of child-bearing potential from exposure to weak D …

Feb 25, 2013 · Anti-D (-RH1) of the Rh blood group system is clinically important as it causes haemolytic transfusion reactions and haemolytic disease of the fetus and newborn. Although most people are either D+ or D−, there is a plethora of D variants, often …

Hemoglobin D (HbD) is a variant of hemoglobin, a protein complex that makes up red blood cells. Based on the locations of the original identification, it has been known by several names such as hemoglobin D-Los Angeles, hemoglobin D-Punjab, [1] D-North Carolina, D-Portugal, D-Oak Ridge, and D-Chicago. [2]

partial, weak, D el variants and D epitopes on RhCe protein • Describe the advantage of a molecular resolution of Rh discrepancies

Red blood cells with partial D antigen type as D-positive, but individuals often produce anti-D when stimulated by transfusion or pregnancy. Some partial D, similar to weak D, result from point mutations in RHD that cause single amino acid changes.

Weak D: Weak D is characterized by a reduced expression of normal D antigens on the red blood cell (RBC) surface. This could result from genetic mutations leading to changes in the RhD protein's structure, affecting its external display on the RBC.

Apr 25, 2016 · Dr. Westhoff helps us navigate this challenging area with an awesome summary of the basics of RhD testing, why and how the results can vary, a description of weak D and partial D, and finally, a potential management strategy for donors with unexpected results.