Mail for the DG postcode area is processed at Carlisle Mail Centre, along with mail for the CA postcode area. The approximate coverage of the postcode districts: DG postcode area map, showing postcode districts in red and post towns in grey text, with links to nearby CA, KA, ML and TD postcode areas. ^ "ONS Postcode Directory Version Notes" (ZIP).

DG9 is a cell-penetrating peptide based on the protein transduction domain of the human Hph-1 transcription factor. Fusion proteins containing this Hph-1 domain have improved delivery in a wide variety of tissues, including the heart ( 27 ); DG9 is comprised of two such Hph-1 domains.

The integration of DG9 into ASO-mediated therapy holds the potential to enhance cellular uptake and biodistribution of PMO, opening the door to more effective and precise treatments for a wide range of disorders.

May 19, 2022 · They found that single intravenous DG9-PMO treatment when compared to unmodified PMO produced 2.2- to 12.3-fold higher skipping and 1.5- to 3.4-fold higher DMD protein levels in skeletal muscles. Additionally, they found 14.4-fold higher skipping and 4.5-fold higher DMD protein levels in the heart.

Mar 1, 2022 · We also found that conjugating DG9, a cell-penetrating peptide, to PMOs improved single-exon 51 skipping, dystrophin restoration, and muscle function in hDMDdel52;mdx mice. Local administration of a minimized exons 45 to 55-skipping DG9-PMO mixture restored dystrophin production.

In today’s #apaperaday, Prof. Aartsma-Rus reads and comments on the paper titled: Development of DG9 peptide-conjugated single- and multi-exon skipping therapies for the treatment of Duchenne muscular dystrophy. Today’s pick from PNASNews is again from the Prof. Toshi Yokota group.

Here, we demonstrate a single subcutaneous administration of cell-penetrating peptide DG9 conjugated to an AO called phosphorodiamidate morpholino oligomer (PMO) reached the CNS and significantly prolonged the median survival compared with unconjugated PMO and R6G-PMO in a severe SMA mouse model.

Oct 2, 2023 · Among these, the DG9 peptide has been identified as a versatile CPP with remarkable potential for enhancing the delivery of ASO-based therapeutics due to its unique structural features. Notably, in the context of phosphorodiamidate morpholino oligomers (PMOs), DG9 has shown promise in enhancing delivery while maintaining a favorable toxicity ...

Aug 29, 2023 · DG9 is a cell-penetrating peptide derived from the protein transduction domain (PTD) of the human Hph-1 transcription factor, which facilitates the cell membrane penetration of its protein cargos in the lungs .

Mar 8, 2023 · Here, we demonstrate a single subcutaneous administration of cell-penetrating peptide DG9 conjugated to an AO called phosphorodiamidate morpholino oligomer (PMO) reached the CNS and significantly prolonged the median survival compared with unconjugated PMO and R6G-PMO in a severe SMA mouse model.