In our recent annotation and genome-wide analysis of lncRNAs in the adult V-SVZ (Ramos et al, Cell Stem Cell 2013), we identified Pnky, a novel lncRNA transcript that is a potent regulator of neural stem cells in the embryonic and postnatal brain (Ramos, Andersen et …

BMS graduate student (PhD, 2021) Discovered dual and genetically separable function of a large subclass of lncRNAs, published in PNAS . Co-authored many, many other papers.

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The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase.

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Soeren Mueller, Aparna Bhaduri, Elizabeth DiLullo, Garima Yagnik, Daniel Lim, Manish Aghi, Arnold Kriegstein, Aaron Diaz. STEM-06. A DRAFT SINGLE-CELL ATLAS OF HUMAN GLIOBLASTOMA REVEALS SPATIAL AND DIFFERENTIATION GRADIENTS OF STEM-LIKE CELLS. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi244-vi245.

Chromatin regulator MLL1 helps neural stem cells "remember" their positional identity as the brain gets larger and anatomically more complex. lncRNAs have exquisitely cell type-specific function. Machine learning identifies predictors of function. Comparison to all coding genes and Perturb-seq reveals unique lncRNA function in neural development.