The SET-CAN/NUP214 fusion gene resulting from chromosomal del (9) (q34.11q34.13) or t (9;9) (q34;q34) has been found in T-cell acute lymphoblastic leukemia (T-ALL), B-cell acute lymphoblastic leukemia (B-ALL), acute myeloid leukemia (AML) and myeloid sarcoma (MS).

Jan 23, 2009 · SET-NUP214 fusion resulting from a recurrent cryptic deletion, del (9) (q34.11q34.13) has recently been described in T-cell acute lymphoblastic leukemia (T-ALL) and in one case of acute myeloid leukemia (AML).

SET-CAN/NUP214 fusion gene is formed by del (9) (q34.11;q34.13) or t (9;9) (q34;q34) and has been identified in the LOUCY cell line of T -ALL and the MEGAL cell line of AML (1, 2). In 1992, Von Lindern et al. first identified the SET-CAN/NUP214 fusion gene in a case of acute undifferentiated leukemia (AUL).

Jul 29, 2022 · Background: The SET-CAN/NUP214 fusion gene resulting from chromosomal del (9) (q34.11q34.13) or t (9;9) (q34;q34) has been found in T-cell acute lymphoblastic leukemia (T-ALL), B-cell acute lymphoblastic leukemia (B-ALL), …

Feb 23, 2016 · Cryptic t(9;9)(q34;q34) and del(q34.11q34.13) are rare genetic abnormalities that lead to the formation of the SET nuclear proto-oncogene (SET)-nucleoporin (NUP)214 fusion gene, which is a marker of acute leukemia (1–12).

We have identified a 9q34.3 deletion in each of five unrelated patients, including a patient with clinical features similar to Opitz trigonocephaly C syndrome (OTCS; MIM 211750).

Nov 20, 2009 · SET-NUP214 rearrangement at chromosome 9q34 is an extremely rare recurrent cryptic deletion resulting from del (9) (q34.11q34.13) mainly found in T-cell acute lymphoblastic leukemia (T-ALL).

Nov 20, 2009 · SET-NUP214 rearrangement at chromosome 9q34 is an extremely rare recurrent cryptic deletion resulting from del(9)(q34.11q34.13) mainly found in T-cell acute lymphoblastic leukemia (T-ALL).

Jan 23, 2009 · Results of fluorescence in situ hybridization (FISH) and array-based copy number analysis were both consistent with del(9)(q34.11q34.13) as described. Quantitative genomic PCR also confirmed loss of genomic material between SET and NUP214 in both cell lines.

9q34 deletion syndrome is a rare genetic disorder. Terminal deletions of chromosome 9q 34 have been associated with childhood hypotonia, a distinctive facial appearance and developmental disability. The facial features typically described include arched eyebrows, small head circumference, midface hypoplasia, prominent jaw and a pouting lower lip.