DOPAL, an intermediate in the degradation of DA, is then oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by ALDH1A1 or reduced to 3,4-dihydroxyphenylethanol (DOPET) by aldose/ aldehyde reductase. Potentially damaging oxygen radicals are formed by …

Jul 13, 2017 · Aldehyde dehydrogenase 1 (ALDH1A1)–positive dopaminergic (DA) neurons at the ventral substantia nigra pars compacta (SNpc) preferentially degenerate in Parkinson’s disease (PD). Their...

Physiologically, ALDH1A1 detoxifies DOPAL, a dopamine metabolite that is toxic by MAO‐B, into 3,4‐dihydroxyphenylacetic acid (DOPAC). Consequently, fragmentation of ALDH1A1 enhanced SH‐SY5Y cell death, which was further augmented by DOPAL.

Dopamine (A), DOPAC (B), HVA (C), DOPAC to DA ratio (D) and HVA to DA ratio (E) were measured in the neostriatum of Aldh1a1−/−×Aldh2−/− double knockout mice and age-matched wild type...

Aug 23, 2011 · Aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of a superfamily of detoxification enzymes found in various tissues that participate in the oxidation of both aliphatic and aromatic aldehydes. In the brain, ALDH1A1 participates in the metabolism of catecholamines including dopamine (DA) and norepine …

May 27, 2014 · ALDH1A1 mediates the oxidation of reactive dopamine-3,4-dihydroxyphenylacetaldehyde (DOPAL) into 3,4-dihydroxyphenylacetic acid (DOPAC), which is then degraded to form homovanillic acid in DA neurons .

Our experiments reveal an evolutionarily conserved GABA synthesis pathway mediated by aldehyde dehydrogenase 1a1 (ALDH1a1). Moreover, GABA co-release is modulated by ethanol at binge drinking blood alcohol concentrations and diminished ALDH1a1 leads to enhanced alcohol consumption and preference.

Feb 22, 2012 · Dopamine (A), DOPAC (B), HVA (C), DOPAC to DA ratio (D) and HVA to DA ratio (E) were measured in the neostriatum of Aldh1a1 −/− ×Aldh2 −/− double knockout mice and age-matched wild type controls. Pathways by which dopamine is …

Dec 10, 2014 · Recently, we have demonstrated that aldehyde dehydrogenase 1 (ALDH1A1) is one such molecular determinant that defines and protects an SNpc DA neuron subpopulation preferentially affected in PD.

May 16, 2021 · ALDH1A1 is a key enzyme to mediate the biosynthesis of retinoic acids (McCaffery and Drager, 1994) and catabolism of reactive dopamine metabolites (Marchitti et al., 2007; Burke, 2010) in DANs.