EPH receptor A2 (ephrin type-A receptor 2) is a protein that in humans is encoded by the EPHA2 gene. [5][6] This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system.

Nov 19, 2018 · Herein, we present a novel mechanism by which EphA2 regulates Wnt/β-catenin signaling. EphA2 acts as a receptor for Wnt ligands and recruits Axin1 to the plasma membrane by directly binding...

EphA2 belongs to the largest known family of protein tyrosine kinase receptors, the Eph family, and two Eph receptors, A and B, have corresponding ligands. The normal cellular function of EphA2 in epithelial tissue is not completely understood, but in cancer, EphA2 modulates cell growth, survival, migration, and angiogenesis ( Pasquale, 2008 ).

Dec 25, 2024 · EPHA2 (EPH Receptor A2) is a Protein Coding gene. Diseases associated with EPHA2 include Cataract 6, Multiple Types and Aniridia. Among its related pathways are GPCR Pathway and ERK Signaling.

Several recent studies have aimed to alter or redirect T cells to target Eph receptors on cancerous cells using unique approaches including the generation of chimeric antigen receptor (CAR) T cells in which the T cell receptor recognizes EphA2 (155–157).

Nov 19, 2018 · Herein, we present a novel mechanism by which EphA2 regulates Wnt/β-catenin signaling. EphA2 acts as a receptor for Wnt ligands and recruits Axin1 to the plasma membrane by directly binding Dvl2.

Eph receptor expression analyses showed that EphA2 co-localized with ephrin-A5, and that the absence of ephrin-A5 reduced the tyrosine phosphorylation of EphA2, suggesting that EphA2 is one of the receptors mediating ephrin-A5 function in the lens.

Jan 4, 2025 · Title: The EphA2 Receptor Regulates Invasiveness and Drug Sensitivity in Canine and Human Osteosarcoma Cells. EphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma.

EphA2 Is a Lung Epithelial Cell Receptor for Pneumocystis beta-Glucans. EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma. CircPAG1 Inhibits the High Glucose-Induced Lens Epithelial Cell Injury by Sponging miR-630 and Upregulating EPHA2.

Feb 23, 2024 · The protein encoded by the ephrin type-A receptor 2 (EphA2) gene is a member of the ephrin receptor subfamily of the receptor tyrosine kinase family (RTKs). Eph receptors play a significant role in various biological processes, particularly cancer progression, development, and …