EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the EPHA3 gene. [5][6][7] This gene belongs to the ephrin receptor subfamily of the protein-tyrosine …

Dec 25, 2024 · EPHA3 (EPH Receptor A3) is a Protein Coding gene. Diseases associated with EPHA3 include Hematologic Cancer and Glioma Susceptibility 1. Among its related pathways …

Eph receptors bind ephrins on neighboring cells, generating cell contact-dependent bidirectional signals that regulate cell shape, movement, survival and proliferation (1; 3; 4). Eph “forward” …

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in …

Eph receptors and ephrins mediate cell-to-cell signaling that controls spatiotemporal tissue organization. The signal transduction mechanism is complex and creates bi-directional cell-to …

Oct 18, 2016 · EphA3 targeting reduces in vitro adhesion and invasion and in vivo growth and angiogenesis of multiple myeloma cells.

Here we highlight the role of EphA3 in normal and malignant tissues that are specific to cancer; these include hematologic disorders, gastric cancer, glioblastoma multiforme, colorectal …

Astrocytic ephrin-A3 reverse signaling mediated by EphA4 receptor is necessary for controlling the abundance of glial glutamate transporters under physiological conditions. However, the …

There is evidence too that Eph receptor signalling influences cell proliferation and cell-fate determination and growing recognition that Eph receptors function in adult tissue homeostasis. …

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into …