Aug 16, 2020 · The epigenome is the set of chemical modifications to the DNA and DNA-associated proteins in the cell, which alter gene expression, and are heritable (via meiosis and mitosis). The modifications occur as a natural process of development and tissue differentiation, and can be altered in response to environmental exposures or disease.

In biology, the epigenome of an organism is the collection of chemical changes to its DNA and histone proteins that affects when, where, and how the DNA is expressed; these changes can be passed down to an organism's offspring via transgenerational epigenetic inheritance.

Mar 8, 2025 · The term epigenome is derived from the Greek word epi which literally means "above" the genome. The epigenome consists of chemical compounds that modify, or mark, the genome in a way that tells it what to do, where to do it, and when to do it. Different cells have different epigenetic marks.

Sep 20, 2022 · That is, there is a secondary form of genomically encoded heritable information, termed ‘epigenetic’ information, which is embedded in chromatin modifications and manifested as canalized pathway choices during differentiation and development, first proposed by Conrad Waddington in the 1940s. 1–5.

Even in differentiated cells, signals fine-tune cell functions through changes in gene expression. A flexible epigenome allows us to adjust to changes in the world around us, and to learn from our experiences.

Epigenetics is the study of these chemical reactions and the factors that influence them. The epigenome dynamically responds to the environment. Stress, diet, behavior, toxins, and other factors regulate gene expression.

Epigenomics is the study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome. The field is analogous to genomics and proteomics, which are the study of the genome and proteome of a cell.

Jan 31, 2025 · Epigenetics refers to how your behaviors and environment can cause changes that affect the way your genes work. Unlike genetic changes (mutations), epigenetic changes are reversible and do not change the sequence of DNA bases, but they can change how your body reads a DNA sequence.

Feb 18, 2015 · The combination of changes in gene expression in a cell is called its epigenome. For more than a decade, scientists have had access to a reference human genome.

Jan 8, 2025 · The advent of single-molecule, long-read sequencing (LRS) technologies by Oxford Nanopore Technologies and Pacific Biosciences has revolutionized genomics, transcriptomics and, more recently,...