Fas signaling pathway involves activating apoptosis (programmed cell death). This happens through the interaction of Fas receptor and Fas ligand. As mentioned, Fas ligand/FasL is a type II transmembrane protein that can exist in both membrane-anchored and soluble forms.

FASL-FAS signaling triggers apoptosis through FADD (Fas-associated protein with death domain, also called MORT1) adaptor protein-mediated recruitment and activation of the aspartate-specific cysteine protease, caspase-8.

FasL is a TNF-related type II transmembrane molecule of ~ 40 kDa but can also be cleaved from the membrane by a metalloprotease, while soluble human FasL can induce apoptosis, soluble mouse FasL cannot.

Aug 7, 2014 · Fas-Fas Ligand Signaling Induces Host Cell Death by Apoptosis. Fas ligand (FasL, CD95L) is a type-II membrane protein within the tumor necrosis factor (TNF) superfamily of death receptors .

We have evaluated the role of the endogenous Fas–Fas ligand (FasL) interaction in the induction of this spontaneous apoptosis and found that a Fas–immunoglobulin (Ig) fusion protein, an antagonistic anti-Fas monoclonal antibody and a rabbit anti-FasL antibody all greatly reduced the onset of apoptosis.

Jan 1, 1997 · Currently, three major immunologically related functions for Fas and FasL have been identified: (i) Fas/FasL interactions influence the development of lymphocytes in the peripheral tissues; (ii) FasL expression on effector lymphocytes can initiate the killing of Fas-expressing malignant or virusinfected cells; and (iii) Fas/FasL interactions ...

Fas activation triggers apoptosis in many cell types. Studies with anti-Fas antibodies have produced conflicting results on Fas signaling, particularly the role of the Bcl-2 family in this process.

What is the Fas pathway and its role in cells? The Fas cell signaling pathway has a central role in the physiological regulation of programmed cell death (also called apoptosis) and has been implicated in the pathogenesis of various malignancies and diseases of the immune system.

A cascade of specific proteases termed caspases mediates the apoptotic process. The activated caspases cleave various cellular components, a process that leads to morphological changes of the cells and nuclei, as well as to degradation of the chromosomal DNA.

Oct 1, 2009 · Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of chronic immune responses 1,2,3 and prevention of autoimmunity...