Nov 4, 2021 · Patients with three-vessel coronary artery disease have been found to have better outcomes with coronary-artery bypass grafting (CABG) than with percutaneous coronary intervention (PCI), but...

Aug 21, 2023 · FAME 3 (Fractional Flow Reserve versus Angiography for Multivessel Evaluation) is an investigator-initiated, multicenter, international, randomized trial involving patients with 3-vessel coronary artery disease (not involving the left …

Nov 1, 2021 · In FAME 3, William F. Fearon, MD, FACC, and colleagues, randomized 1,500 patients at 48 centers in Europe, North America, Australia and Asia to either FFR-guided PCI (n=750) or CABG (n=750). All patients had three-vessel CAD, no left main involvement, and were deemed amenable by the heart team for both PCI and CABG.

Dec 22, 2023 · Highlighted text has been updated as of December 22, 2023. The FAME 3 trial demonstrated that FFR-guided PCI using current-generation DES did not meet criteria for noninferiority compared with CABG among patients with angiographic three-vessel disease.

By incorporating FFR-guided PCI and utilizing the 2nd generation Resolute Integrity stent, FAME 3 aims to demonstrate that FFR-guided PCI is non-inferior to CABG in patients with 3-vessel coronary disease not involving the left main coronary artery.

May 17, 2024 · PARIS, France—Among patients with three-vessel disease, contemporary fractional flow reserve (FFR)-guided PCI is more cost-effective compared with CABG surgery 3 years later, according to a new analysis of the FAME 3 study.

Sep 19, 2022 · We evaluate the prognostic value of measuring fractional flow reserve (FFR) after percutaneous coronary intervention (post-PCI FFR) and intravascular imaging in patients undergoing PCI for 3-vessel coronary artery disease in the FAME 3 trial (Fractional Flow Reserve versus Angiography for Multivessel Evaluation).

The FAME 3 study will compare in a multicenter, randomized fashion FFR-guided PCI with contemporary drug-eluting stents to CABG in patients with 3-VD.

The FAME 3 (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation 3) trial compared FFR-guided PCI with CABG in patients with angiographic 3-vessel CAD. In this prespecified substudy, the angiographic core laboratory calculated the SYNTAX score (SS) and then the FSS by eliminating lesions that were not significant based on FFR.

Nov 4, 2021 · In the FAME 3 study, presented at TCT 2021 and published simultaneously in the New England Journal of Medicine, patients treated with FFR-guided PCI had a higher rate of death from any cause, MI, stroke, or repeat revascularization that those treated with surgery, missing the noninferiority margin established by investigators.