
Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass ...
Nov 4, 2021 · Patients with three-vessel coronary artery disease have been found to have better outcomes with coronary-artery bypass grafting (CABG) than with percutaneous coronary intervention (PCI), but...
Fractional Flow Reserve–Guided PCI or Coronary Bypass Surgery for 3 …
Aug 21, 2023 · FAME 3 (Fractional Flow Reserve versus Angiography for Multivessel Evaluation) is an investigator-initiated, multicenter, international, randomized trial involving patients with 3-vessel coronary artery disease (not involving the left …
FAME 3: FFR-Guided PCI vs. CABG in Patients With Three-Vessel …
Nov 1, 2021 · In FAME 3, William F. Fearon, MD, FACC, and colleagues, randomized 1,500 patients at 48 centers in Europe, North America, Australia and Asia to either FFR-guided PCI (n=750) or CABG (n=750). All patients had three-vessel CAD, no left main involvement, and were deemed amenable by the heart team for both PCI and CABG.
Fractional Flow Reserve Versus Angiography for Multivessel Evaluation 3 ...
Dec 22, 2023 · Highlighted text has been updated as of December 22, 2023. The FAME 3 trial demonstrated that FFR-guided PCI using current-generation DES did not meet criteria for noninferiority compared with CABG among patients with angiographic three-vessel disease.
By incorporating FFR-guided PCI and utilizing the 2nd generation Resolute Integrity stent, FAME 3 aims to demonstrate that FFR-guided PCI is non-inferior to CABG in patients with 3-vessel coronary disease not involving the left main coronary artery.
PCI for Multivessel Disease More Cost-effective Than CABG at 3 …
May 17, 2024 · PARIS, France—Among patients with three-vessel disease, contemporary fractional flow reserve (FFR)-guided PCI is more cost-effective compared with CABG surgery 3 years later, according to a new analysis of the FAME 3 study.
Prognostic Value of Measuring Fractional Flow Reserve After ...
Sep 19, 2022 · We evaluate the prognostic value of measuring fractional flow reserve (FFR) after percutaneous coronary intervention (post-PCI FFR) and intravascular imaging in patients undergoing PCI for 3-vessel coronary artery disease in the FAME 3 trial (Fractional Flow Reserve versus Angiography for Multivessel Evaluation).
Rationale and design of the Fractional Flow Reserve versus ... - PubMed
The FAME 3 study will compare in a multicenter, randomized fashion FFR-guided PCI with contemporary drug-eluting stents to CABG in patients with 3-VD.
Outcomes Based on Angiographic vs Functional Significance of Complex 3 ...
The FAME 3 (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation 3) trial compared FFR-guided PCI with CABG in patients with angiographic 3-vessel CAD. In this prespecified substudy, the angiographic core laboratory calculated the SYNTAX score (SS) and then the FSS by eliminating lesions that were not significant based on FFR.
FAME 3: PCI Fails to Demonstrate Noninferiority to Surgery in …
Nov 4, 2021 · In the FAME 3 study, presented at TCT 2021 and published simultaneously in the New England Journal of Medicine, patients treated with FFR-guided PCI had a higher rate of death from any cause, MI, stroke, or repeat revascularization that those treated with surgery, missing the noninferiority margin established by investigators.