May 21, 2021 · Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play an important role in cancer initiation, progression, and …

CAFs have been shown to originate primarily from resident tissue fibroblasts (or stellate cells) or from mesenchymal cells recruited to the TME from the bone marrow.

Jun 10, 2021 · To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME), and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Aug 5, 2022 · In the present review, we aimed to take a deep look at the mechanobiology of CAFs and TAMs in tumor progression and to discuss the available therapeutic approaches for …

Cancer-associated fibroblasts (CAFs) and immune cells make up two major components of the tumor microenvironment (TME), contributing to an ecosystem that can either support or …

A cancer-associated fibroblast (CAF) (also known as tumour-associated fibroblast; carcinogenic-associated fibroblast; activated fibroblast) is a cell type within the tumor microenvironment that …

Oct 3, 2023 · Schematic diagram of the interaction of CAF with cells in LC, CRC, PCa, and Melanoma TME. CAF-secreted exosome LINC01614 activates the NF-κB signaling pathway, …

Feb 10, 2023 · As one of the main components of TME, CAFs interact with cancer cells and immune cells by secreting cytokines and vesicles, participating in ECM remodeling, and finally …

Jul 3, 2023 · CAFs, also known as activated fibroblasts, are central to the reactive stroma within the TME, as they not only interact extensively with cancer cells via secreted molecules or …

Cancers contain a suite of genetically stable cells within an extracellular matrix, collectively termed the tumor microenvironment (TME). The TME strongly influences disease outcome for …