
Furin - Wikipedia
Furin is a protease, a proteolytic enzyme activated by substrate presentation that in humans and other animals is encoded by the FURIN gene. Some proteins are inactive when they are first …
FURIN AT THE CUTTING EDGE: FROM PROTEIN TRAFFIC TO …
In this review, I summarize the various features of furin: its structural and enzymatic properties, autoactivation, intracellular localization and trafficking; its substrates; and its roles in vivo, …
What are Furin Proteases? - News-Medical.net
Mar 9, 2021 · Originally identified in 1990, furin is a cellular endoprotease that proteolytically activates many proprotein substrates ranging from pathogenic agents to growth factors, …
Furin - an overview | ScienceDirect Topics
Furin (human) is a 794 residue Type I transmembrane protein with a large lumenal segment, including signal peptide, pro-, catalytic, P or “homoB,” and Cys-rich domains, a …
Furin Enzyme: Structure, Function, and Therapeutic Implications
Jul 14, 2024 · The furin enzyme is a member of the proprotein convertase family, characterized by its ability to cleave precursor proteins at specific sites. Structurally, furin is a type I …
Furin‐mediated protein processing in infectious diseases and cancer
In this review, we describe the physiological and pathophysiological substrates of furin and discuss how dysregulation of a simple proteolytic cleavage event may promote infectious …
Japanese Wind Chimes (Furin): A Guide to Types, Characteristics, …
Jan 21, 2025 · Wind chimes (furin) are traditional Japanese items that herald the arrival of summer with their refreshing sounds. With a rich history, these decorative pieces have been …
Furin Cleavage Site Prediction: Implications for Biology
3 days ago · Furin is expressed across various tissues, with distribution and activity levels tailored to each organ’s physiological demands. High secretory activity tissues, such as the liver, …
Designing the Furin-Cleavable Linker in Recombinant …
Intracellular cleavage of native PE by furin is required for cytotoxicity, yet the PE cleavage site has been shown to be a poor furin substrate. Here we describe the rational design of more …
Bi-cycling the furin pathway: from TGN localization to pathogen ...
Jan 1, 1999 · Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to …
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