Furin is a protease, a proteolytic enzyme activated by substrate presentation that in humans and other animals is encoded by the FURIN gene. Some proteins are inactive when they are first …

In this review, I summarize the various features of furin: its structural and enzymatic properties, autoactivation, intracellular localization and trafficking; its substrates; and its roles in vivo, …

Mar 9, 2021 · Originally identified in 1990, furin is a cellular endoprotease that proteolytically activates many proprotein substrates ranging from pathogenic agents to growth factors, …

Furin (human) is a 794 residue Type I transmembrane protein with a large lumenal segment, including signal peptide, pro-, catalytic, P or “homoB,” and Cys-rich domains, a …

Jul 14, 2024 · The furin enzyme is a member of the proprotein convertase family, characterized by its ability to cleave precursor proteins at specific sites. Structurally, furin is a type I …

In this review, we describe the physiological and pathophysiological substrates of furin and discuss how dysregulation of a simple proteolytic cleavage event may promote infectious …

Jan 21, 2025 · Wind chimes (furin) are traditional Japanese items that herald the arrival of summer with their refreshing sounds. With a rich history, these decorative pieces have been …

3 days ago · Furin is expressed across various tissues, with distribution and activity levels tailored to each organ’s physiological demands. High secretory activity tissues, such as the liver, …

Intracellular cleavage of native PE by furin is required for cytotoxicity, yet the PE cleavage site has been shown to be a poor furin substrate. Here we describe the rational design of more …

Jan 1, 1999 · Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to …