GFAP splice isoforms show differential expression patterns in the human brain. GFAPδ is preferentially expressed by neurogenic astrocytes in the subventricular zone (SVZ), whereas GFAP (+1) is found in a subset of astrocytes throughout the brain.

Apr 1, 2024 · This study describes a first mouse brain atlas of region and cell type-specific expression of gene isoforms. These isoforms are quantified, and the dataset includes Gfap isoforms.

Glial fibrillary acidic protein (GFAP) is an intermediate filament structural protein involved in cytoskeleton assembly and integrity, expressed in high abundance in activated glial cells. GFAP is neuroprotective, as knockout mice are hypersensitive to traumatic brain injury.

Aug 19, 2021 · Cluster 4 expresses classical white matter genes Vim and Gfap in the control brain but is primarily defined by inflammatory markers including Lcn2, Ifitm3 and Timp1 after inflammation.

Immunofluorescence is a powerful tool to investigate changes in the expression of neuronal and glial proteins and to map activated brain areas at the cellular level. This imaging technique enables the visualization of highly specific protein (antigen) targets using a combination of primary and secondary antibodies.

Feb 3, 2022 · Glial fibrillary acidic protein (GFAP) levels reflect the clinical severity and extent of intracranial pathology after traumatic brain injury (TBI). In 2018, the FDA authorized the...

Aug 13, 2012 · GFAP splice isoforms show differential expression patterns in the human brain. GFAPδ is preferentially expressed by neurogenic astrocytes in the subventricular zone (SVZ), whereas GFAP +1 is found in a subset of astrocytes throughout the brain.

In a search for targets of miR-3099, Abidin et al. (2017) identified the mouse Gfap gene based on sequence analysis of mouse 3’UTRs by a battery of algorithms, and by an inverse correlation between the presence of Gfap mRNA and miR-3099 in various mouse brain regions.

Oct 24, 2004 · Transgenically targeted cell fate mapping showed that essentially all neuroblasts and neurons newly generated in the adult mouse forebrain in vivo, and in adult multipotent neurospheres in vitro,...

GFAP mRNA and protein showed generalized increases in old mice. Major white fiber tracts, such as the corpus callosum, fimbria, stria terminalis, and optic tract, showed increased GFAP immunostaining and mRNA.