The exon 3-deleted growth hormone receptor: molecular and
The GH receptor (GHR) plays a key role in the the function of the GH/IGF-I axis and is the major effector of human growth. A common polymorphic variant consisting of genomic exon 3 …
The Exon 3-Deleted Growth Hormone Receptor (d3GHR) …
Molecular regulation of GH is accomplished via the GH receptor (GHR), which is the main factor influencing human development and is essential to optimal functioning of the GH/IGF-I axis. …
Exon-3 Deletion of the Growth Hormone Receptor (GHR) Gene …
Jan 1, 2010 · The article by Bernabeu et al. (1) in this issue of JCEM again brings into discussion the effects of genomic variability at the GH receptor (GHR) locus on the response to medical …
Influence of growth hormone (GH) receptor deletion of exon 3
Context: A polymorphism of the GH receptor (GHR) gene resulting in genomic deletion of exon 3 (GHR-d3) has been associated with responsiveness to GH therapy. However, the data …
The GH receptor exon 3 deletion is a marker of male-specific ...
The d3-GHR genetic variant polymorphism modulates GH responsiveness throughout life span and positively affects male longevity. Keywords: growth hormone receptor, IGF-I, positive …
The Growth Hormone Receptor: Mechanism of Receptor Activation…
Growth hormone activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the …
GHR exon 3 polymorphism: association with type 2 diabetes ... - PubMed
This study investigates these GHR variants in subjects with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT), including Type 2 diabetes mellitus (T2DM). DNA was …
The growth hormone receptor exon 3-deleted/full-length …
Jun 1, 2015 · In this study we evaluated d3-GHR as a possible cause of increased GH sensitivity in children with DICT and the impact of the GHR d3/fl polymorphism on GH treatment …
The GH receptor exon 3 deletion is a marker of male-specific
Jun 16, 2017 · Because a GH receptor exon 3 deletion (d3-GHR) appears to modulate GH sensitivity in humans, we hypothesized that this polymorphism could play a role in human …
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