Growth hormone–releasing hormone (GHRH), also known as somatocrinin among other names in its endogenous form and as somatorelin in its pharmaceutical form, is a releasing hormone of growth hormone (GH). It is a 44 [1]-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus.

GHRH and its analogues regulate cell growth, proliferation, differentiation, and survival through complex networks of signaling pathways involving GHRH/GH/IGF-1 and/or local activation of GHRH receptors on extrapituitary systems and paracrine/autocrine loops.

May 18, 2015 · The primary regulation factors are growth hormone-releasing hormone (GHRH) produced in the hypothalamus, somatostatin, produced in various tissues throughout the body, and ghrelin, which is produced in the gastrointestinal tract. GHRH functions to promote HGH production and release.

This review focuses on our current understanding of how growth hormone releasing hormone (GHRH): 1) stimulates GH release and synthesis from pituitary growth hormone (GH)-producing cells (somatotropes), 2) drives somatotrope proliferation, 3) is negatively regulated by somatostatin (SST), GH and IGF …

Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or by several other names, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.

Growth hormone-releasing hormone (GHRH) is produced by the hypothalamus and stimulates growth hormone synthesis and release in the anterior pituitary gland. In addition, GHRH is an important regulator of cellular functions in many cells and organs.

Two hypothalamic hormones regulate hGH; they are growth hormone-releasing hormone (GHRH) and growth hormone-inhibiting hormone (GHIH). When blood glucose levels fall, GHRH triggers the secretion of stored hGH.

Nov 23, 2024 · In particular, a key role is played by the hypothalamic peptides growth hormone-releasing hormone (GHRH) and somatostatin, which regulate the somatotroph axis with opposite actions, stimulating and inhibiting GH release, respectively.

Growth hormone-releasing hormone (GHRH) is an endocrine hormone produced in the hypothalamus and works on its receptor (GHRH-R) in the anterior pituitary to stimulate the release of growth hormone (GH).

Its secretion from the pituitary is regulated by the neurosecretory nuclei of the hypothalamus, which can release Growth hormone-releasing hormone (GHRH or somatocrinin) and Growth hormone-inhibiting hormone (GHIH or somatostatin) into the hypophyseal portal venous blood surrounding the pituitary.