Recent experimental work implicates transforming growth factor-beta (TGF-beta) as an aetiologic mediator of diabetic nephropathy and the ubiquitous glucose transporter GLUT1 as an important permissive factor for the tissue injury caused by hyperglycaemia.

This study examined the effects of TGF-β1-mediated pathways on GLUT1 expression in vivo and in vitro, explored the relationship between GLUT1 and TGF-β1 and further investigated the potential underlying mechanisms.

Because the linkage between glucose metabolism and ECM protein production was found in mesangial cells overexpressed with the brain-type glucose transporter (GLUT1), we hypothesized that TGF-beta 1 could affect glucose metabolism.

The data indicate that glucose transportation via GLUT1 is implicated in the PRR-dependent upregulation of TGF-β while CTGF is mediated mainly via a mechanism depending on ROS formation in renal medullary collecting duct cells.

May 1, 1999 · TGF-β1 stimulates glucose uptake by enhancing GLUT1 expression in mesangial cells. An increase in the expression of transforming growth factor-β1 (TGF-β1) has been proposed to play an important role in the excessive production of extracellular matrix (ECM) proteins seen in …

The results link Glut1 repression and reduced glucose uptake to the anti-proliferative response of TGF-β1 and indicate that re-expression of Glut1 and increased glucose uptake during chronic TGF-β1 exposure allow breast cancer cells to develop a …

Aug 1, 2016 · Here, we address these important issues and show that: 1) up-regulation of GLUT1 by TGF-β in fibroblasts is a general phenomenon; 2) GLUT1 induction and activity are critical for profibrotic TGF-β signaling; 3) enhanced GLUT1 expression is observed in the lungs of patients with idiopathic pulmonary fibrosis (IPF) and in the bleomycin mouse ...

Dec 1, 1999 · Recent experimental work implicates transforming growth factor- β (TGF- β) as an aetiologic mediator of diabetic nephropathy and the ubiquitous glucose transporter GLUT1 as an important permissive factor for the tissue injury caused by hyperglycaemia.

Nephrol Dial Transplant. 2000 Sep;15 (9):1476-7. doi: 10.1093/ndt/15.9.1476.

Jan 1, 2000 · Recent experimental work implicates transforming growth factor-β (TGF-β) as an aetiologic mediator of diabetic nephropathy and the ubiquitous glucose transporter GLUT1 as an important...