Sep 1, 2000 · Gap junctions are membrane channels that mediate the cell-to-cell movement of ions and small metabolites. In the heart, gap junctions play an important role in impulse …

Gap junctions (GJs) are specialized cell–cell contacts that mediate conduction in the heart. The tight correlation between decreased CV and remodeling of GJ protein expression, post …

Adjacent to the intercalated discs are the gap junctions, which allow action potentials to directly spread from one myocyte to the next. More specifically, the disks join the cells together by …

May 1, 2004 · Gap junctions play a pivotal role for the velocity and the safety of impulse propagation in cardiac tissue. Under physiologic conditions, the specific subcellular distribution …

Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes, allowing the existence of electrical coupling. However, in addition to this fundamental role, connexins …

Gap junction remodeling in cardiac disease involves changes in connexin expression, resulting in altered gap junction density and functional coupling, as well as changes in gap junction …

Jun 23, 2000 · Abstract—Connexins, the protein molecules forming gap junction channels, are reduced in number or redistributed from intercalated disks to lateral cell borders in a variety of …

Electrical activation of the heart requires cell-cell transfer of current via gap junctions, arrays of densely packed protein channels that permit intercellular passage of ions and small molecules.

Jul 30, 2022 · Intercalated discs are part of the cardiac muscle sarcolemma and they contain gap junctions and desmosomes. Contractions of the heart (heartbeats) are controlled by …

Electrical coupling between cardiac muscle cells is mediated by specialised sites of plasma membrane interaction termed gap junctions, one of three types of intercellular junction of the …