In conclusion, these findings reveal that Z-IETD-FMK specifically and effectively blocks the activity of cattle granzyme B and inhibits the killing of target cells by bovine CD8 + T cells, indicating …

Granzyme B Inhibitor II The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used …

We found that stimulation of memory CD4 + T cells by ANC28.1, as well as by conventional costimulation (CD3/CD28 mAb), robustly induced enzymatically active GrzB, along with …

Granzyme B is a serine protease enzyme predominantly expressed in cytotoxic T lymphocytes and natural killer (NK) cells. It plays a crucial role in inducing apoptosis in target cells, a …

Buy high-quality Z-IETD-FMK, a potent and selective inhibitor of Caspase-8. Functionally validated in TNF-α-induced necroptosis cellular assays. Each lot is highly pure (≥95%) and …

Granzyme B (GrB), acting similar to an apical caspase, efficiently activates a proteolytic cascade after intracellular delivery by perforin. Studies here were designed to learn whether the …

Ac- IETD- CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac- IETD- CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac- IETD- CHO also …

Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor. Z-IETD-FMK is also a granzyme B inhibitor. - Mechanism of Action & Protocol.

Nov 23, 2023 · Purpose: This study aimed to evaluate whether granzyme B (GzmB)-targeted positron emission tomography (PET) imaging agent (68 Ga-grazytracer) can characterize …

Granzyme B Substrate I, Colorimetric, Ac-IETD- pNA, Caspase-8 Substrate I, Ac-IETD-pNA, Caspase-8 Substrate I. Sign In to View Organizational & Contract Pricing. Select a Size. 5 …