In this review, we focus on the compositional changes in the gut microbiome and its related metabolites in various CVDs. Moreover, the potential treatment and preventive strategies targeting the gut microbiome and its metabolites are discussed.

The exploration of the gut-cardiac axis marks a pivotal advancement in cardiovascular health, revealing the critical interplay between the gut and the heart. This connection, once underappreciated, is now recognized for its significant impact on cardiac well-being.

The gut–heart axis offers promising avenues for MI management, with dietary interventions, personalized probiotics, and exercise regimens emerging as key strategies to modulate gut microbiota and reduce cardiovascular risk.

Nov 20, 2024 · Myocardial infarction (MI) remains the leading cause of death globally, imposing a significant burden on healthcare systems and patients. The gut-heart axis, a bidirectional network connecting gut health to cardiovascular outcomes, has recently emerged as a critical factor in MI pathophysiology.

In this review, we focus on the compositional changes in the gut microbiome and its related metabolites in various CVDs. Moreover, the potential treatment and preventive strategies targeting the gut microbiome and its metabolites are discussed.

May 8, 2019 · In light of our recent findings of dietary fiber intake being negatively associated with dysbiosis in HF, dietary intervention with a high-fiber diet, alone or in combination with a Mediterranean diet, could be a logical next step for targeting the gut heart axis.

The interaction between the intestinal microbiota and the heart occurs via metabolites of bacterial origin, which are resorbed in the intestine and distributed via the circulation. Bacterial metabolites are produced from food components, which in turn emphasizes the importance of nutrition.

Oct 1, 2021 · The relatively novel concept of the ‘gut-heart axis’ has been proposed to describe the connection between the gut microbiome profile and cardiac homeostasis. Upon intestinal absorption, gut-derived substances flow through the heart before entering the arterial circulation.

Aug 23, 2017 · Patients with heart failure (HF) have structural and functional changes of the gut as a result of microcirculatory disturbances. A disrupted gut epithelial barrier may lead to translocation of microbial products into systemic circulation, possibly aggravating HF by inducing inflammatory responses.

Mar 17, 2025 · The gut-heart axis possesses a bidirectional communication between the systemic circulation and gut microorganisms, characterised by their interaction and communication with one another [9, 10].GM plays a pivotal role in modulation of systemic inflammation, lipid metabolism, and vascular homeostasis and its interaction with cardiovascular system (CVS) is primarily mediated by microbial ...