The understanding of the process of viral replication, HBV-HDV interactions, and etio-pathogenesis of the severe course of HDV infection is helpful in identifying the potential therapeutic targets in the virus life cycle for the prophylaxis and treatment of …

Hepatitis D virus (HDV) is a small satellite virus of hepatitis B virus (HBV) requiring HBV infection to complete its life cycle. It has been recently estimated that 13% of chronic HBV...

This review includes an overview of the HBV and HDV viruses, including life cycle, structure, natural course of infection, and histopathology. A discussion of the interplay between HDV RNA and HBV DNA during chronic infection is also included.

While physiologically distinct, HBV and HDV life cycles are closely linked. HDV is a deficient virus that relies on HBV to fulfil is viral cycle. As a result, the cellular response to HDV also influences HBV replication.

HDV is considered the most severe viral hepatitis with rapid progression toward liver-related death and HCC. 1 It is a circular single-stranded RNA virus with negative polarity and was first described in 1977 in patients either coinfected or super-infected with HBV. Most recent developments in understanding the HDV lifecycle have led to ...

Dec 27, 2013 · The understanding of the process of viral replication, HBV-HDV interactions, and etio-pathogenesis of the severe course of HDV infection is helpful in identifying the potential therapeutic...

HDAg-S is produced in the early stages of an infection and enters the nucleus and supports viral replication.

Jul 5, 2023 · The life cycle of HDV requires the hepatitis B surface antigen (HBsAg) provided by hepatitis B virus (HBV). 1 Like HBV, HDV is transmitted by the parenteral route through infectious...

Dec 27, 2013 · The understanding of the process of viral replication, HBV-HDV interactions, and etio-pathogenesis of the severe course of HDV infection is helpful in identifying the potential therapeutic targets in the virus life cycle for the prophylaxis and treatment of …

Hepatitis D Virus (HDV) Structure, Life Cycle, and Antiviral Targets. Circulating HDV virion comprises an envelope that consists of large (L), middle (M), and small (S) HBV surface antigens (HBsAg) and a ribonucleoprotein with genomic HDVRNA complexed with 2 isoforms of hepatitis D antigen (S-HDAg and L-HDAg).