Hexokinase 2 (HK2) is widely distributed in various tissues, particularly showing significantly elevated expression levels in tumor tissues. As the initial rate-limiting enzyme in the glycolysis …

Hexokinase 2 (HK2) is the most active isozyme of the family, mainly expressed in insulin-sensitive tissues. HK2 induction in most neoplastic cells contributes to their metabolic rewiring towards …

potential of targeting HK2 for cancer therapy is promising, and with these challenges addressed, natural products inhibiting HK2 will play an even greater role in the fight against cancer. …

In this study, we used TCGA and GEO databases to conduct pan-cancer analysis of HK2, including the expression of the HK2 gene in different tumors, the effect of HK2 on tumor …

The current review is focused on HK2 inhibition, envisaging the development of potent and selective anticancer agents. The information on function, expression, and activity of HKs is …

Sep 17, 2019 · In this article, we explored the roles of HK2 in the tumorigenesis of cervical cancer with a goal of obtaining new information that could improve the prevention and treatment of …

These results revealed a critical non-metabolic function of HK2 in promotion of cancer cell stemness. Our findings provided new insights into the multifaceted roles of HK2 in tumor …

Feb 1, 2023 · HK2 inhibition suppresses HCC proliferation under hypoxic stimulation compared to normoxic conditions (Gwak et al., 2005). HK2 is also indispensable for glycolysis, proliferation, …

Dec 1, 2020 · This book is a record of that journey as we explore "Cancer as a Metabolic Disease" and the repurposed drugs and supplements targeting metabolic pathways for …