Hydroxychavicol is a phenylpropanoid compound present in leaves of Piper betle. [1] It is a more potent inhibitor of xanthine oxidase (IC 50 =16.7 μM) than allopurinol. [2] [3]

Hydroxychavicol (HC), a primary constituent of P. betle leaves, is known to possess antiproliferative activity at micromolar doses on various cancer cell lines of different origins while leaving normal cells unharmed.

Hydroxychavicol is a major phenolic compound present in the aqueous extract of the Piper betle leaf, which is extensively consumed as betel quid in the Indian subcontinent. The compound is better known for its antioxidant and anticancer properties (1, 9).

Nov 29, 2016 · Among them, hydroxychavicol is the major phenolic component that belongs to relatively new class (allylbenzene) of natural compounds which has remarkable therapeutic potential. In our earlier...

Hydroxychavicol is the most important bioactive compound among the wide range of phytoconstituents found in essential oil and extracts. The pharmacological attributes of P. betle are antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal and many ...

Mar 27, 2024 · Hydroxychavicol (HCH), a constituent of the alcoholic extract of Piper betle leaves, was evaluated for anti-CML activity.

May 20, 2018 · Hydroxychavicol (HC) from Piper betle possesses antibacterial activity. HC induces DNA damage and inhibits cell division. HC damages iron sulfur proteins leading to amplification of oxygen radicals. HC is active against clinical bacteria of …

Aug 8, 2007 · Hydroxychavicol (HC), a betel leaf component, was tested for its antiplatelet effect. We tested the effect of HC on platelet aggregation, thromboxane B 2 (TXB 2) and reactive oxygen species (ROS) production, cyclooxygenase (COX) activity, ex vivo platelet aggregation and mouse bleeding time and platelet plug formation in vivo.

This study aims to elucidate the antiproliferative mechanism of hydroxychavicol (HC). Its effects on cell cycle, apoptosis, and the expression of c-Jun N-terminal kinase (JNK) and P38 mitogen-activated protein kinase (MAPK) in HT-29 colon cancer ...

Hydroxychavicol also exhibited potent antioxidant and anti-inflammatory activities. This was evident from its concentration-dependent inhibition of lipid peroxidation and significant suppression of tumor necrosis factor alpha expression in human neutrophils.