Dec 7, 2023 · It can be applied topically or injected into skin (often referred to as i-PRF, short for injectable PRF) to target signs of aging. The most common treatment areas for PRF are the face (especially dark under-eye circles), neck, and hands.

This single-center, prospective, uncontrolled study evaluated the efficacy of injectable platelet-rich fibrin (i-PRF) for facial skin rejuvenation using an objective skin analysis system and validated patient-reported outcome measures. PRF ® PROCESS system technology was used to prepare i …

Injectable platelet-rich fibrin (I-PRF) is a second generation, fully autologous, blood-derived biomaterial having three-dimensional fibrin meshwork, like that of a PRF clot, while retaining the fluid nature, just like platelet-rich plasma (PRP).

In this study, a liquid formulation of platelet rich fibrin (PRF) termed injectable-PRF (i-PRF) without the use of anti-coagulants was investigated. Materials and methods: Standard PRP and i-PRF (centrifuged at 700 rpm (60G) for 3 min) were compared for growth factor release up to 10 days (8 donor samples).

However, the injection of solid PRF membrane is not possible. Following extensive basic research, Miron et al. observed that by further reducing the centrifugal force (g force) and the time duration of spin, a liquid PRF can be prepared. This was termed as Injectable-PRF or I-PRF. The centrifugal speed was kept at 60 g for 3 min.

This overview and narrative review provided many updates on the use of injectable PRF and its increasingly widespread use over the past 10 years. The following key messages should be derived from the article:

Injectable platelet-rich fibrin (i-PRF) was developed to act as a regenerative agent that could be delivered in liquid formulation [65,66]. To achieve this, blood is drawn rapidly in a specific centrifugation tube at a low speed (approximately 700 rpm for 3 minutes).

A series of three i-PRF injections resulted in significant rejuvenation of the face skin at 3-month follow-up, as shown by improved skin analysis parameters and patient self-assessment scores.

2 days ago · With the introduction of the low-speed centrifugation concept (LSCC) for developing and optimizing PRF, 25, 26 injectable platelet-rich fibrin (i-PRF) was introduced as a liquid form of PRF with shorter centrifugation protocols. 27-31 According to the LSCC, it was hypothesized that a slower, shorter centrifugation process could result in a ...

However, recent research provided new protocol for liquid variation of PRF called injectable PRF (i-PRF). This injectable form of PRF is produced by using blood without anticoagulant and centrifuged at 700 rpm (60 g) for 3 min in plastic tubes without any coatings [ 46 ].