Visit https://www.uab.edu/research/home/irap and click IRAP Training for details. IRAP staff are available to assist you and can be reached at 975-IRAP (975-4727) or This email address is …

Feb 3, 2025 · It provides guidance on the 2018 Requirements set forth in 45 CFR 46.114 (b) (1) that require any institution located in the United States engaged in cooperative research to rely on approval by a single institutional review board (IRB) for that portion of the research that is conducted in the United States, with some exceptions as described at ...

Scan the Investigator's Progress Report (IPR) with the materials referenced in the IPR (Problem Summary Sheet, annual reports, DSMB reports, etc.) in one document named ipr.YYMMDD.

Propose a Single IRB: Identify an IRB of record and ensure that the chosen IRB is willing and able to serve as the reviewing IRB for the research (i.e., obtain a letter of support from the Office of the IRB identified as the reviewing IRB for the cooperative research project).

All domestic sites must use a single IRB of record to review human subjects research when participating in NIH supported multi-site studies whether that support comes from a grant, cooperative agreement, contract, or the NIH IRP.

These lessons include distinguishing the roles of the single IRB from institutional Human Research Protections programs, establishing a consistent sIRB review model, standardizing collection of local context and supplemental, study-specific information, and educating and empowering lead study teams to support their sites.

When reviewing for a multi-site study, the Reviewing IRB can also be referred to as the ‘single IRB (sIRB),’ ‘IRB of record’ or ‘Central IRB.’. NIH can function as one or a combination of these designations. Is the NIH IRB the appropriate to serve as the reviewing sIRB? Make the protocol as general as possible.

Apr 4, 2023 · Revisions to the Common Rule and NIH policy require the use of a single Institutional Review Board (sIRB) for the review of most federally funded, multisite research, with the intent of streamlining the review process.

To learn more about the SMART IRB reliance agreement and confirm whether your collaborators have signed on, please visit: www.smartirb.org. How is Johns Hopkins handling requests to serve as a sIRB?

Implementation of a single IRB represents a shift in practice and culture for many institutions. Evaluation of the reliance arrangements for this study highlights both the potential of, and challenges for, institutions as they transition to single IRB review.