Kavain is the main kavalactone found mostly in the roots of the kava plant. Kavain has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. [1] .

Feb 8, 2023 · Kava is an extract that comes from a shrub called Piper methysticum, which is native to Micronesia and Polynesia. “The root is emulsified to make an intoxicating beverage,” Dr. Goldman explains. “It can also be dried and used as a dietary supplement to …

In this study, we characterised the functional properties of the major anxiolytic kavalactone, kavain at human recombinant α1β2, β2γ2L, αxβ2γ2L (x = 1, 2, 3 and 5), α1βxγ2L (x = 1, 2 and 3) and α4β2δ GABA A Rs expressed in Xenopus oocytes using the …

Jan 23, 2025 · Discover kavain, a key anxiolytic extract from kava, rich in kavalactones. Learn about its active constituents, molecular effects, and clinical trials.

Discover the perfect balance of organic kava and the best of modern extraction methods. Kavain is proud to offer access to Fiji and Vanuatu’s finest noble kava in 2025. We have been busy collecting over 600 samples over the past 18 months on a joint PPP research assignment.

Kavain | C14H14O3 | CID 5281565 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Aug 30, 2024 · Kava, a shrub from the pepper family, contains active ingredients called kavalactones that produce a calming, relaxing effect and help relieve anxiety. Some people also use kava supplements to lift depression and treat insomnia. Researchers are exploring its potential for stopping the growth of certain cancers.

Noteworthy, kavain, the most potent anxiolytic kavalactone, as well as dihydrokavain and yangonin were largely ineffective in the highest tested concentrations.

The neurophysiological activities of Piper methysticum are attributed primarily to the lipophilic resinous compounds, known as kavalactones (also known as kava pyrones), found in the root.

Jun 22, 2016 · In this study, we characterised the functional properties of the major anxiolytic kavalactone, kavain at human recombinant α1β2, β2γ2L, αxβ2γ2L (x = 1, 2, 3 and 5), α1βxγ2L (x = 1, 2 and 3) and α4β2δ GABAARs expressed in Xenopus oocytes using the two-electrode voltage clamp technique.