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SiRNA is a potential therapeutic candidate to reverse hepatic fibrogenesis due to its high specificity and effectiveness in downregulating genes related to liver fibrogenesis. siRNAs can specifically down-regulate target mRNA in a sequence-specific recognition way .

Jan 29, 2025 · RNAi therapy, particularly siRNA, aims to silence genes essential for tumor growth, metastasis, and therapy resistance. In this study, previously developed linear peptides containing tryptophan and histidine/arginine were screened for synthesizing gold nanoparticles.

In the present study we investigated calcineurin dependent or independent cytotoxic effects of CsA, a calcineurin inhibitor, in cervical cancerous SiHa cells. Decreased cell viability and massive cytoplasmic vacuolations were observed in CsA treated SiHa …

This review focuses on the chemical perspectives behind non-viral siRNA delivery systems, including siRNA synthesis, siRNA conjugates, and nanoparticle delivery using nucleotides, lipids, and polymers.

4 days ago · siRNA is a negatively charged and double-stranded RNA molecule of 21–23 nt. siRNA exerts its effects through RNAi, allowing selective targeting and high specificity. 6 It expands drug targets to upstream RNAs of functional proteins, regulating the expression of target genes at the post-transcriptional level.

Aug 30, 2024 · RNAi therapy, particularly siRNA, aims to silence genes essential for tumor growth, metastasis, and therapy resistance. In this study, previously developed linear peptides containing tryptophan and histidine/arginine were screened for synthesizing gold nanoparticles.

One of the most important advances in biology has been the discovery that siRNA (small interfering RNA) is able to regulate the expression of genes, by a phenomenon known as RNAi (RNA interference). The discovery of RNAi, first in plants and ...

GAPDH siRNA using (a) AuNP-W2R4, (b) AuNP-W3R3 and (c) AuNP-W4R4 in MCF 7 cell line.

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