Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene. [5][6] This gene encodes a serine/threonine protein kinase belonging to the LATS tumor …

Dec 25, 2024 · LATS2 (Large Tumor Suppressor Kinase 2) is a Protein Coding gene. Diseases associated with LATS2 include Malignant Peritoneal Mesothelioma and Liposarcoma Of Bone. …

Feb 21, 2022 · Induction of LATS2 contributes to p53 tumor suppressive functions through a positive feedback mechanism, wherein the LATS2 protein promotes p53 stabilization by …

To understand novel functions of LATS2, we constructed a LATS2 knockout HeLa-S3 cell line using TAL-effector nuclease (TALEN). Integrated omics profiling of this cell line revealed that …

May 1, 2016 · We discovered that Ser872 T-loop and Thr1041 hydrophobic motif (HM) phosphorylation of LATS2 is essential for LATS2 activation. MST1/2 phosphorylate LATS2 on …

Jun 29, 2007 · We show that the Mob1 family, a regulator of mitotic exit, associates with Lats2 to induce its activation. We also show that the complete LATS2 -knock-out cells exhibit an …

LATS2 expression is also regulated by TTP (tristetraprolin), an ARE (AU-rich element) binding protein that promotes the degradation of ARE-containing transcripts , and at least six different …

Jan 10, 2014 · We analyzed the involvement of the tumor-suppressor Lats2 in mouse embryonic stem cell (mESC) pluripotency and differentiation, and report that mESCs lacking Lats2 are …

LATS2 - Explore an overview of LATS2, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data.

Jan 10, 2024 · Here we report that LATS2, the core kinase of the Hippo pathway, responds to F-actin cytoskeleton reduction and forms condensates. The proline-rich motif (PRM) of LATS2 …