ALDH2 mitigates LPS-induced cardiac dysfunction, inflammation, …
Dec 20, 2023 · We demonstrated that ALDH2 alleviated LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS/STING signaling pathway, thereby protecting …
Mitochondrial ALDH2 protects against lipopolysaccharide …
Jun 1, 2019 · Recent evidence depicted an essential role for mitochondrial aldehyde dehydrogenase (ALDH2) in cardiac homeostasis. This study examined the effect of ALDH2 on …
Macrophage ALDH2 (Aldehyde Dehydrogenase 2) Stabilizing …
Mar 31, 2022 · ALDH2 (aldehyde dehydrogenase 2) stabilizes Rac2 by attenuating Rac2 ubiquitination. A and B, Primary peritoneal macrophages were transfected with LV-con or LV …
Aldehyde dehydrogenase 2 inhibits inflammatory response …
Jun 14, 2016 · Previous studies demonstrated that aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which eliminates ALDH2 activity down to 1%-6%, is a susceptibility gene for …
The role of aldehyde dehydrogenase 2 in cardiovascular disease
Feb 13, 2023 · Aldehyde dehydrogenase 2 (ALDH2) detoxifies alcohol-derived acetaldehyde and lipid peroxidation-generated aldehydes, and its inactivating rs671 polymorphism is present in …
Advances in Factors Affecting ALDH2 Activity and its Mechanisms
Oct 4, 2024 · This review aims to provide a comprehensive overview of the latest advancements in factors affecting ALDH2 activity, encompassing post-transcriptional modifications, …
Frontiers | Aldehyde Dehydrogenase 2 Protects Against ...
May 6, 2021 · ALDH2 plays a major role in protecting cells from the effects of acetaldehyde and fatty acid-derived aldehydes, such as 4-hydroxy-trans-2-nonenal (4HNE), by oxidizing them to …
Acetaldehyde dehydrogenase 2 interactions with LDLR and …
Jan 2, 2019 · Acetaldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme detoxifying acetaldehyde and endogenous lipid aldehydes; previous studies suggest a protective role of …
Targeting Aldehyde Dehydrogenase 2: New Therapeutic …
In addition to the well-characterized inhibitors of ALDH2, new research tools, including more selective inhibitors, transgenic mice with altered ALDH2 activity, and selective ALDH2 …
ALDH2通过线粒体融合与裂变减轻脂多糖诱导的脑微血管内皮细胞 …
观察乙醛脱氢酶2 (ALDH2)对脂多糖 (LPS)诱导的小鼠脑微血管内皮细胞屏障的影响，并探讨线粒体融合与裂变在内皮屏障中的作用。 小鼠脑微血管内皮细胞分为3组：对照组：不给予任何处 …
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