Currently studying the molecular mechanisms of neuronal regeneration, specifically in the context of the optic nerve and glaucomatous neurodegeneration.

Here we review the current understanding regarding the temporal progression of axonal degeneration. We summarize known survival and regenerative mechanisms in mammals, including specific signaling pathways, key transcription factors, and reprogramming genes.

Mar 30, 2023 · Using this assay, we find that map3k12, also known as dual leucine zipper kinase (Dlk), is necessary for RGC axonal regeneration and acts in a dose-dependent manner.

We cover mechanisms intrinsic to retinal ganglion cells as well as their interactions with myeloid and glial cell populations in the retina and optic nerve that affect survival and regeneration.

Lindsay Fague, Yin Allison Liu, Nicholas Marsh-Armstrong UC Davis Eye Center, Department of Ophthalmology & Vision Science, University of California, Davis, Sacramento, CA, USA Contributions: (I) Conception and design: L Fague, N Marsh-Armstrong; (II) Administrative support: None; (III) Provision of study material or

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Purpose : To present the results of longitudinal in vivo visualization and quantification of Retinal Ganglion Cells (RGCs) and Retinal Nerve Fiber Layer (RNFL) bundles in mice following Optic Nerve Crush (ONC).

Aug 13, 2021 · We cover mechanisms intrinsic to retinal ganglion cells as well as their interactions with myeloid and glial cell populations in the retina and optic nerve that affect survival and regeneration.