Jun N-terminal kinases (JNKs) and p38 mitogen-activated protein kinases (MAPKs) have important roles in the signalling mechanisms that orchestrate cellular responses to many types of...

Mar 1, 2002 · MAPK pathways relay, amplify and integrate signals from a diverse range of stimuli and elicit an appropriate physiological response including cellular proliferation, differentiation,...

Mitogen-activated protein kinase (MAPK) modules containing three sequentially activated protein kinases are key components of a series of vital signal transduction pathways that regulate processes such as cell proliferation, cell differentiation, and cell death in eukaryotes from yeast to humans (Fig. 1) (Qi and Elion 2005; Raman et al. 2007 ...

Consequently, dual-specificity MKKs (MAPK kinases) may represent more attractive targets. In particular, evidence that blocking JNK activation by removing MKK4 offers an effective therapy to treat pathological conditions has started to emerge.

Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members function in a cell context-specific and cell type-specific manner to integrate signals that affect proliferation, differentiation, survival and migration.

Oct 30, 2023 · Purpose: Mitogen-activated protein kinases (MAPK), specifically the c-Jun N-terminal kinase (JNK)-MAPK subfamily, play a crucial role in the development of various cancers, including hepatocellular carcinoma (HCC).

Oct 30, 2023 · To explore the role of components of JNK–MAPK pathway played in HCC progression, this study analyzed the gene expression profile of MAPK8 (JNK1), MAPK9 (JNK2), MAP2K4 (MKK4), and MAP2K7 (MKK7) in HCC using RNA-seq datasets from TCGA.

We briefly discuss new findings in the extracellular signaling-regulated kinase (ERK) pathway, but mainly focus on the mechanisms how stress activated MAPK pathways, such as p38 MAPK and the Jun N-terminal kinases (JNK), impact the response of cancer cells to chemotherapies and targeted therapies.

Mar 28, 2014 · The Mitogen Activated Protein Kinase (MAPK) pathway plays a key role in the development and progression of cancer [1]. The classical MAPK pathway consists of the extracellular-signal-regulated kinase (ERK), the c-jun N-terminal kinase or stress-activated protein kinase (JNK or SAPK); and MAPK14 [2].

As a member of the mitogen-activated protein kinase (MAPK) family, JNK is also known as stress-activated kinase (SAPK) because it can be activated by extracellular stresses including growth factor, UV irradiation, and virus infection.