Jul 11, 2018 · Mitochondrial calcium uptake is critical for regulating ATP production, intracellular calcium signalling, and cell death. This uptake is mediated by a highly selective calcium channel called the...

The mitochondrial calcium uniporter (MCU) is a transmembrane protein that allows the passage of calcium ions from a cell's cytosol into mitochondria. Its activity is regulated by MICU1 and MICU2, which together with the MCU make up the mitochondrial calcium uniporter complex. [1]

Mitochondrial calcium (mtCa 2+) uptake is ensured by the presence in the inner mitochondrial membrane (IMM) of the mitochondrial calcium uniporter (MCU) complex, a macromolecular structure composed of pore-forming and regulatory subunits. MtCa 2+ uptake plays a crucial role in the regulation of oxidative metabolism and cell death.

May 2, 2016 · Mitochondrial calcium uniporter (MCU) is the pore-forming and Ca 2+-conducting subunit of the uniporter holocomplex, but its primary sequence does not resemble any calcium channel studied to...

Mar 3, 2020 · The mitochondrial calcium uniporter (MCU) plays a critical role in mitochondrial calcium uptake into the matrix. In metazoans, the uniporter is a tightly regulated multicomponent system, including the pore-forming subunit MCU and several regulators (MICU1, MICU2, and Essential MCU REgulator, EMRE).

Jun 18, 2013 · Here we show that exogenously expressed Mcu is mitochondrially localized and increases mitochondrial Ca 2+ levels following NMDA receptor activation, leading to increased mitochondrial membrane...

Aug 25, 2023 · Mitochondrial calcium (mtCa 2+) uptake is ensured by the presence in the inner mitochondrial membrane (IMM) of the mitochondrial calcium uniporter (MCU) complex, a macromolecular structure composed of pore-forming and regulatory subunits.

Accordingly, a rapid electrogenic pathway (denoted the “mitochondrial calcium uniporter” (MCU)) was described that rapidly transports Ca 2+ into the matrix, driven by the negative charge of the membrane potential (ΔΨ) established by the respiratory chain.

Mitochondrial calcium uptake plays critical roles in regulating ATP production, intracellular calcium signaling, and cell death. This uptake is mediated by a highly selective calcium channel called the mitochondrial calcium uniporter. Here, we ...

Mitochondrial calcium uptake is critical for regulating ATP production, intracellular calcium signalling, and cell death. This uptake is mediated by a highly selective calcium channel called...