Apr 12, 2024 · We conducted untargeted lipidomics across 13 biological samples from mice at various life stages (2, 12, 19 and 24 months) to explore the potential link between aging and lipid metabolism,...

In this review, we summarize the accelerated aging mouse models, both in systematic whole-body and in specific organs. Although systemic-induced accelerated aging mouse models mimic natural aging, it is not fully equal to natural aging.

In the present study, we characterized functional aging in male C57BL/6J mice using a multi-domain behavioral test battery. The results derived from mice are translated to a human aging phenotype and discussed in terms of frailty (Fried et al., 2001; Vellas, 2016).

2 days ago · Caloric restriction is associated with slow aging in model organisms. Additionally, some drugs have also been shown to slow aging in rodents. To better understand metabolic mechanisms that are involved in increased lifespan, we analyzed metabolomic differences in six organs of 12-month-old mice using five interventions leading to extended longevity, specifically caloric restriction, 17-α ...

Mar 13, 2025 · Generally, mice accumulate mutations 20 times faster than humans and it has been hypothesized that this might in some way be linked to why their lifespan is shorter. However, the team showed that in blood from mice, the rate of accumulation of mutations was much lower than expected – only three times higher than humans.

Laboratory mice, compared to people, present important advantages for investigations of the biological underpinnings of aging, late-life illness, and age-dependent physiological changes.

1 day ago · Aging altered the gene expression profile of the colon of the mice. The molecular mechanism underlying the effect of aging on gut function was explored next, for which colonic RNA sequencing was ...

Jul 18, 2024 · In this review, we present a comprehensive overview of the characteristics, limitations, applicability, bone phenotypes, and treatment methods in naturally aging mice and prematurely aging mouse models (including SAMP6, POLG mutant, LMNA, SIRT6, ZMPSTE24, TFAM, ERCC1, WERNER, and KL/KL -deficient mice).

Mar 31, 2021 · In this large population mouse study, inbred C57BL/6J and outbred UM-HET3 mice of both sexes are longitudinally evaluated for functional, phenotypic, and biological health, and collection of biospecimens is conducted throughout their life span.

2 days ago · Sarcopenia, a chronic degenerative condition associated with aging, is characterized by a significant decline in muscle mass and strength. Puerarin, a major active isoflavone extracted from Pueraria lobata, exhibits potent anti-inflammatory and antioxidant properties. However, its therapeutic effects on sarcopenia remain unclear. Thus, the purpose of this study was to evaluate the therapeutic ...